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  • MKC3946
  • 货号: abs819027
    CAS号: 1093119-54-0
    分子式: C21H20N2O3S
    分子量: 380.46
    产品说明书
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    货号-规格 货期 价格 数量
    abs819027-1mg 1-2周 ¥1848.00
    - +
    abs819027-5mg 1-2周 ¥5880.00
    - +
    大包装询价
    产品描述
    描述
    MKC3946 is a potent and soluble IRE1α inhibitor, used for cancer research.
    基本信息
    可溶性/溶解性
    DMSO
    生物活性
    靶点
    IRE1α endoribonuclease
    In vitro(体外研究)
    MKC-3946 triggers modest growth inhibition in MM cell lines, without toxicity in normal mononuclear cells. Importantly, it significantly enhances cytotoxicity induced by bortezomib or 17-AAG, even in the presence of bone marrow stromal cells or exogenous IL-6. Both bortezomib and 17-AAG induce ER stress, evidenced by induction of XBP1s, which is blocked by MKC-3946. Apoptosis induced by these agents is enhanced by MKC-3946, associated with increased CHOP. MKC-3946 treatment does not inhibit IRE1α kinase function or binding of activated IRE1α to TRAF2 and downstream JNK signaling.
    In vivo(体内研究)
    MKC-3946 inhibits XBP1 splicing in a model of ER stress in vivo, associated with significant growth inhibition of MM cells.
    参考文献
    参考文献
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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