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  • MK-886 (L-663,536)
    货号: abs816225
    CAS号: 118414-82-7
    分子式: C27H34ClNO2S
    分子量: 472.08
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs816225-5mg 1-2周 ¥849.00
    - +
    abs816225-25mg 1-2周 ¥2790.00
    - +
    abs816225-100mg 1-2周 ¥6791.00
    - +
    大包装询价
    产品描述
    描述
    MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.
    纯度
    99.24 %
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    可溶性/溶解性
    体外:
    DMSO 94mg/mL(199.11mM)
    Water <1mg/mL
    Ethanol <1mg/mL

    生物活性
    靶点
    5-lipoxygenase-activating protein (FLAP),PPARα,COX-1,COX-2
    In vitro(体外研究)
    MK-886, an inhibitor of the 5-lipoxygenase-activating protein (FLAP), potently suppresses leukotriene biosynthesis in intact cells and is frequently used to define a role of the 5-lipoxygenase (EC 1.13.11.34) pathway in cellular or animal models of inflammation, allergy, cancer, and cardiovascular disease. MK-886 inhibits isolated COX-1 (IC50=8 μM) and blocks the formation of the COX-1-derived products 12(S)-hydroxy-5-cis-8,10-trans-heptadecatrienoic acid (12-HHT) and thromboxane B2 in washed human platelets in response to collagen as well as from exogenous arachidonic acid (IC50=13–15 μM).Isolated COX-2 was less affected (IC50=58 μM), and in A549 cells, MK-886 (33 μM) failed to suppress COX-2-dependent 6-ketoprostaglandin (PG)F1α formation. MK-886 (10 μM) inhibits COX-1-mediated platelet aggregation induced by collagen or arachidonic acid whereas thrombin- or U-46619-induced (COX-independent) aggregation is not affected.
    In vivo(体内研究)
    Repeated daily i.p. injections of MK-886 results in increased GluR1 phosphorylation in brain samples obtained from the prefrontal cortex. In contrast, a single injection of MK-886 does not alter cortical GluR1 phosphorylation.
    参考文献
    参考文献
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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