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  • (-)-MK 801 maleate

    • MK 801; MK801; C13737
    货号: abs810778
    CAS号: 121917-57-5
    分子式: C20H19NO4
    分子量: 337.37
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    货号-规格 货期 价格 数量
    abs810778-10mg 现货 ¥463.00
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    abs810778-50mg 现货 ¥1709.00
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    大包装询价
    产品描述
    描述

    (-)-MK 801 Maleate is the enantiomer of (+)-MK-801; (+)-MK-801 is a highly potent and selective non-competitive NMDA glutamate receptor antagonist .

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    MK 801; MK801; C13737
    外观
    Powder
    可溶性/溶解性
    DMSO:67 mg/mL (198.59 mM)

    Ethanol:7 mg/mL (20.74 mM)

    生物活性
    靶点
    NMDA receptor
    In vitro(体外研究)
    Neurophysiological studies in vitro, using a rat cortical-slice preparation, demonstrates a potent, selective, and noncompetitive antagonistic action of dizocilpine on depolarizing responses to N-Me-D-Asp but not to kainate or quisqualate. The potencies of phencyclidine, ketamine, SKF 10047, and the enantiomers of dizocilpine as N-Me-D-Asp antagonists correlate closely (r = 0.99) with their potencies as inhibitors of dizocilpine binding. This suggests that the dizocilpine binding sites are associated with N-Me-D-Asp receptors and provides an explanation for the mechanism of action of dizocilpine as an anticonvulsant.
    In vivo(体内研究)
    All the control rats have severe permanent neurological deficits after ischemic spinal cord injury (ISCI), whereas the dizocilpine–treated rats have statistically (P
    参考文献
    参考文献
    [1] Wong EH et al., Proc Natl Acad Sci U S A, 1986, 83(18), 7104-7108.
    [2] Wise-Faberowski L et al., J Neurosurg Anesthesiol, 2006, 18(4), 240-246.
    [3] Kocaeli H et al., Surg Neurol, 2005, 64 Suppl 2, S22-S26.
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