(-)-MK 801 maleate
- MK 801; MK801; C13737
货号: abs810778
货号-规格 | 货期 | 价格 | 数量 |
abs810778-10mg | 现货 | ¥463.00 | - + |
abs810778-50mg | 现货 | ¥1709.00 | - + |

产品描述 | ||
描述 | (-)-MK 801 Maleate is the enantiomer of (+)-MK-801; (+)-MK-801 is a highly potent and selective non-competitive NMDA glutamate receptor antagonist . | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | MK 801; MK801; C13737 | |
外观 | Powder | |
可溶性/溶解性 | DMSO:67 mg/mL (198.59 mM) Ethanol:7 mg/mL (20.74 mM) | |
生物活性 | ||
靶点 | NMDA receptor | |
In vitro(体外研究) | Neurophysiological studies in vitro, using a rat cortical-slice preparation, demonstrates a potent, selective, and noncompetitive antagonistic action of dizocilpine on depolarizing responses to N-Me-D-Asp but not to kainate or quisqualate. The potencies of phencyclidine, ketamine, SKF 10047, and the enantiomers of dizocilpine as N-Me-D-Asp antagonists correlate closely (r = 0.99) with their potencies as inhibitors of dizocilpine binding. This suggests that the dizocilpine binding sites are associated with N-Me-D-Asp receptors and provides an explanation for the mechanism of action of dizocilpine as an anticonvulsant. | |
In vivo(体内研究) | All the control rats have severe permanent neurological deficits after ischemic spinal cord injury (ISCI), whereas the dizocilpine–treated rats have statistically (P | |
参考文献 | ||
参考文献 | [1] Wong EH et al., Proc Natl Acad Sci U S A, 1986, 83(18), 7104-7108.
[2] Wise-Faberowski L et al., J Neurosurg Anesthesiol, 2006, 18(4), 240-246. [3] Kocaeli H et al., Surg Neurol, 2005, 64 Suppl 2, S22-S26. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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