(+)MK-801 maleate
- Dizocilpine maleate; Dizocilpine hydrogen maleate; (+)-MK 801; MK 801; MK801
货号: abs810777
货号-规格 | 货期 | 价格 | 数量 |
abs810777-10mg | 现货 | ¥386.00 | - + |
abs810777-100mg | 1-2周 | ¥2239.00 | - + |

产品描述 | ||
描述 | Dizocilpine maleate(MK 801) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | Dizocilpine maleate; Dizocilpine hydrogen maleate; (+)-MK 801; MK 801; MK801 | |
外观 | Powder | |
可溶性/溶解性 | DMSO :67 mg/mL (198.59 mM) Ethanol :7 mg/mL (20.74 mM) | |
生物活性 | ||
靶点 | NMDA receptor | |
In vitro(体外研究) | MK-801 labels high-affinity binding sites in rat cerebral cortical membranes in a saturable manner. MK-801 produces a potent blockade of depolarizing responses to NMDA in rat cerebral cortical slices. The only compounds that are able to compete for MK-801 binding sites are substances known to block the responses of excitatory amino acids mediated by the NMDA receptor subtype. MK-801 inhibits N-methyl-D-aspartate-induced norepinephrine (NE) release and TCP binding in the hippocampus with IC50 of 20 nM and 9 nM, respectively. MK-801 causes a progressive, long-lasting blockade of current induced by NMDA. Mg2+ (10 mM) prevents MK-801 from blocking the N-Me-D-Asp-induced current, even when MK-801 is applied for a long time in the presence of NMDA. MK-801 is also effective at blocking NMDA-activated single-channel activity in outside-out patches. MK-801 ( | |
In vivo(体内研究) | Treatment of mice with MK-801 (1 mg/kg) before each METH injection reduced the extent of DA depletion by 55% in striatal of mice. MK-801 (1 mg/kg) attenuates the effects of METH on microglial activation in striatal of mice. MK-801 (0.05 mg/kg or 0.2 mg/kg, i.p.) in rats just prior to reactivation of the cocaine-associated memory in the CPP context attenuates subsequent cocaine-primed reinstatement, while no disruption occurres in rats that do not receive reactivation in the CPP context. MK-801 (0.2 mg/kg, i.p.) prior to two reactivation sessions in the home cage does not suppress subsequent cocaine-primed reinstatement. | |
参考文献 | ||
参考文献 | [1]. Wong EH, et al. Proc Natl Acad Sci U S A, 1986, 83(18), 7104-7108. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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