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  • (24R)-MC 976

    货号: abs818682
    CAS号: 112828-09-8
    分子式: C27H42O3
    分子量: 414.62
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    abs818682-1mg 1-2周 询价
    大包装询价
    产品描述
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    可溶性/溶解性
    10 mM in DMSO
    参考文献
    参考文献
    [1]. Strugnell, Stephen; Calverley, Martin J.; Jones, Glenville. Metabolism of a cyclopropane ring-containing analog of 1α-hydroxyvitamin D3 in a hepatocyte cell model. Identification of 24-oxidized metabolites. Biochemical Pharmacology (1990), 40(2), 333-41.

    Abstract

    MC 969 is an analog of the calcemic drug 1α-hydroxyvitamin D3 (1α-OH-D3) in which carbons 25, 26, and 27 in the side chain are incorporated into a cyclopropane ring. Metabolites of MC 969 were generated in an in vitro human hepatocyte cell model, Hep 3B. The identity of the metabolites was established by comigration on HPLC with authentic standards, and by mass spectrometry of native and chemically modified metabolites Unequivocal identification of the 24-keto- and the two epimeric 24-alcohol metabolites is provided. No 25-hydroxylated metabolites were detected. In competition studies, MC 969 was able to inhibit 25-hydroxylation of tritiated vitamin D3 more effectively than 1α-OH-D3 itself, indicating that the vitamin D3-25-hydroxylase may be responsible for generation of one or more of the metabolites observed.
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