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  • α-Mangostin

    • α-倒捻子素;Alpha-Mangostin
    货号: abs814701
    CAS号: 6147-11-1
    分子式: C24H26O6
    分子量: 410.46
    产品说明书
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    货号-规格 货期 价格 数量
    abs814701-25mg 1-2周 ¥1379.00
    - +
    abs814701-100mg 1-2周 ¥4907.00
    - +
    大包装询价
    产品描述
    描述
    α-Mangostin is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.
    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    α-倒捻子素;Alpha-Mangostin
    外观
    faint yellow to yellow powder
    可溶性/溶解性
    DMSO : 110 mg/mL (267.99 mM; Need ultrasonic)
    生物活性
    靶点
    IDH1-R132H
    In vitro(体外研究)
    Alpha-mangostin exhibits a selective inhibitory effect on IDH1-R132H, but not on IDH1. Alpha-mangostin competitively inhibits the binding of alpha-mangostin (α-KG) to IDH1-R132H. The structure–relationship study reveals that alpha-mangostin exhibits the strongest core inhibitor structure. Alpha-mangostin selectively promotes demethylation of 5-methylcytosine (5mC) and histone H3 trimethylated lysine residues in IDH1 (+/R132H) MCF10A cells. Cell proliferation significantly decreases in a dose-dependent manner in the cells treated with alpha-mangostin. Alpha-mangostin also increases the levels of Bax (pro-apoptotic), cleaved caspase-3, cleaved caspase-9 and cleaved-poly(ADP-ribose) polymerase (PARP). Alpha-mangostin significantly inhibits light-induced degeneration of photoreceptors and 200 μM Water2-induced apoptosis of RPE cells. 200 μM Water2-induced generation of reactive oxygen species (ROS) and light-induced generation of malondialdehyde (MDA) are suppressed by alpha-mangostin.
    In vivo(体内研究)
    Alpha-mangostin reduces risk of liver fibrosis through the decrease in p53 expression as compared to the TAA_DMSO treatment. The serum levels of the liver enzymes AST and ALT after treatment with α-mangostin decrease as compared to DMSO alone.
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