LR White Resin

Activation of the Akt signaling pathway rescues impaired fracture healing resulting from BTX-induced muscle atrophy. (A) Representative X-rays illustrating fracture callus development in the Control Vehicle group, BTX Vehicle group, BTX SC79 group and BTX MK2206 group at 3, 6 and 9 weeks post-osteotomy. (B) Representative 3D reconstructed images of the external fracture callus and related histomorphometry analysis by micro-CT. Scale bars, 1 mm. (C) Representative images of H & E and Safranin O staining in mid-sagittal sections of the fracture callus in each group at 3, 6 and 9 weeks post-osteotomy. Scale bars, 3 mm. (D) Biomechanical tests of maximum compressive load of the fractured rat femora at 9 weeks postosteotomy. n = 5 animals per group per time point. The data are presented as the mean ± SD. ⁎P < 0.05 versus Control Vehicle group, #P < 0.05 versus BTX Vehicle group. BTX, botulinum toxin-A.