LDC1267
货号: abs817480
货号-规格 | 货期 | 价格 | 数量 |
abs817480-2mg | 1-2周 | ¥728.00 | - + |
abs817480-5mg | 1-2周 | ¥1119.00 | - + |
abs817480-10mg | 1-2周 | ¥1940.00 | - + |
abs817480-50mg | 1-2周 | ¥6413.00 | - + |

产品描述 | ||
描述 | LDC1267 is a highly selective TAM kinase inhibitor with IC50 of <5 nM, 8 nM, and 29 nM for Mer, Tyro3, and Axl, respectively. Displays lower activity against Met, Aurora B, Lck, Src, and CDK8. | |
纯度 | 99% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
可溶性/溶解性 | 10 mM in DMSO | |
生物活性 | ||
靶点 | Mer ,Tyro3 ,Axl | |
In vitro(体外研究) | LDC1267 moderately affects cell proliferation in 11 of 95 different cell lines with IC50 of >5μM. In NKG2D-activated NK cells, LDC1267 abolishes the inhibitory effects of Gas6 stimulation. | |
In vivo(体内研究) | In B16F10 melanoma-bearing mice, LDC1267 (20 mg/kg, i.p.) efficiently enhances anti-metastatic NK cell activity, and rejects tumor metastases without serious cytotoxicity. | |
参考文献 | ||
参考文献 | ||
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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