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  • LCI-699
    • Osilodrostat
    货号: abs811461
    CAS号: 928134-65-0
    分子式: C13H10FN3
    分子量: 227.241
    产品说明书
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    货号-规格 货期 价格 数量
    abs811461-5mg 1-2周 ¥2178.00
    - +
    abs811461-1g 1-2周 ¥21000.00
    - +
    大包装询价
    产品描述
    描述
    LCI699 is a potent inhibitor of human 11β-hydroxylase and aldosterone synthase with IC50 values of 2.5 and 0.7 nM, respectively.
    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    Osilodrostat
    可溶性/溶解性
    DMSO : 250 mg/mL (1100.16 mM; Need ultrasonic)
    Ethanol : 100 mg/mL (440.06 mM; Need ultrasonic)
    生物活性
    靶点
    11β-hydroxylase
    In vitro(体外研究)
    LCI699 also inhibits aldosterone synthase (CYP11B2) other than CYP11B1.
    In vivo(体内研究)
    LCI699 is a potent inhibitor of 11β-hydroxylase (CYP11B1), the enzyme that catalyzes the final step of cortisol synthesis, and has a half-life of ∼4 hours. It decreases blood pressure (BP) in patients with essential hypertension and primary aldosteronism. Treatment with LCI699 is well tolerated, it is demonstrated efficacy with a satisfactory safety and tolerability profile in the proof-of-concept study in Cushing's disease. The administration of LCI699, up to 1.0 mg BID, effectively and safely inhibits aldosterone synthase in patients with primary aldosteronism.
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    • 实验方法 实验条件
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