首页 产品中心
  • LB42708
  • LB-42708;LB 42708
  • 货号: abs813701
    CAS号: 226929-39-1
    分子式: C30H27BrN4O2
    分子量: 555.46
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs813701-5mg 1-2周 ¥813.00
    - +
    abs813701-10mg 1-2周 ¥1402.00
    - +
    abs813701-25mg 1-2周 ¥2125.00
    - +
    abs813701-50mg 1-2周 ¥4212.00
    - +
    大包装询价
    产品描述
    描述

    LB42708 is an orally active farnesyltransferase (FTase) inhibitor with IC50 of 0.8, 1.2, and 2.0 nM toward H-ras, N-ras, and K-ras, respectively.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    LB-42708;LB 42708
    可溶性/溶解性
    Ethanol :55.6 mg/mL (100 mM)

    DMSO :55.6 mg/mL (100 mM)
    生物活性
    靶点
    FTase (H-ras),FTase (N-ras),FTase (K-Ras)
    In vitro(体外研究)
    LB42708 potently inhibits the processing of the cellular farnesylated protein p21ras induced by LPS + IFN-γ in murine macrophage cell line RAW264.7 cells. LB42708 inhibits NF-κB activation and iNOS promoter activity through the inhibition of IKK activity. Moreover, LB42708 suppresses the expression of inducible NO synthase, cyclooxygenase-2, TNF-alpha, and IL-1beta and the production of NO and PGE(2) in immune-activated macrophages and osteoblasts. LB42708 irreversibly inhibits growth and induces apoptosis in H-ras and K-ras-transformed rat intestinal epithelial cells. LB42708 inhibits of VEGF-induced tumor angiogenesis by blocking Ras-dependent MAPK and PI3K/Akt pathways in tumor-associated endothelial cells.
    In vivo(体内研究)
    LB42708 (12.5 mg/kg i.p.) inhibits production of NO, PGE2, TNF-α, and IL-1β in LPS-injected mice, and also prevents the development of CIA. LB42708 (20 mg/kg/day i.p.) also inhibits tumor growth and angiogenesis in both Ras wild-type and mutated tumors.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
        提示: 尊敬的客户您好,如果您对我们的产品有什么疑问或想要了解的,可以点击“我要提问”按钮填写您的疑问。
        提交不成功?请联系info@absin.cn。
        我要提问

    促销资讯 更多

      订购信息
      您可以从我们的授权经销商处购买absin产品或获得技术支持。若要查看您所在地区的经销商,请从以下的下拉列表中选择。
      GO
      • 0