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  • KGA-2727
    • KGA2727
    货号: abs819781
    CAS号: 666842-36-0
    分子式: C26H40N4O8
    分子量: 536.62
    产品说明书
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    货号-规格 货期 价格 数量
    abs819781-5mg 1-2周 ¥2468.00
    - +
    abs819781-25mg 1-2周 ¥7403.00
    - +
    大包装询价
    产品描述
    描述
    KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 exhibits antidiabetic efficacy in rodent models.
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    KGA2727
    可溶性/溶解性
    DMSO :100 mg/mL (186.35 mM)
    Water :100 mg/mL (186.35 mM)
    Ethanol :45 mg/mL (83.86 mM)
    生物活性
    In vitro(体外研究)
    KGA-2727 inhibits SGLT1 potently and highly selectively in an in vitro assay using cells transiently expressing recombinant SGLTs.
    In vivo(体内研究)
    In a small intestine closed loop absorption test with normal rats, KGA-2727 inhibits the absorption of glucose but not that of fructose. In the oral glucose tolerance test with streptozotocininduced diabetic rats, KGA-2727 attenuats the elevation of plasma glucose after glucose loading, indicating that KGA-2727 improves postprandial hyperglycemia. In Zucker diabetic fatty (ZDF) rats, chronic treatments with KGA-2727 reduces the levels of plasma glucose and glycated hemoglobin. Furthermore, KGA-2727 preserves glucose-stimulated insulin secretion and reduces urinary glucose excretion with improved morphological changes of pancreatic islets and renal distal tubules in ZDF rats. In addition, the chronic treatment with KGA-2727 increases the level of glucagon-like peptide-1 in the portal vein.
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    • 实验方法 实验条件
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