- KB R7943; KB-R 7943, KBR7943, 182004-65-5, KB-R7943 mesylate, 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE, IN1281, KB-R 7943
货号: abs810631
货号-规格 | 货期 | 价格 | 数量 |
abs810631-10mg | 1-2周 | ¥958.00 | - + |
abs810631-50mg | 1-2周 | ¥3383.00 | - + |
abs810631-100mg | 1-2周 | ¥6174.00 | - + |

产品描述 | ||
描述 | KB-R7943 mesylate is a potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = 0.7 mM). | |
纯度 | >98% | |
储存/保存方法 | store at -20℃ for one year(Powder);
in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months. | |
基本信息 | ||
别名 | KB R7943; KB-R 7943, KBR7943, 182004-65-5, KB-R7943 mesylate, 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE, IN1281, KB-R 7943 | |
外观 | Powder | |
可溶性/溶解性 | DMSO : ≥ 27 mg/mL H2O : 4.3 mg/mL (Need warming) | |
生物活性 | ||
靶点 | Na(addition)_Ca2(addition) Exchanger | |
In vitro(体外研究) | KB-R7943 mesylate blocks NMDAR-mediated ion currents, and inhibits NMDA-induced increase in cytosolic Ca2+ with IC50=13.4±3.6 µM but accelerates calcium deregulation and mitochondrial depolarization in glutamate-treated neurons. KB-R7943 depolarizes mitochondria in a Ca2+-independent manner. KB-R7943 inhibits 2,4-dinitrophenol-stimulated respiration of cultured neurons with IC50=11.4±2.4 µM. In addition to NCXrev, KB-R7943 dose-dependently and reversibly blocked ion currents elicited by NMDA. KB-R7943 dose-dependently inhibits NMDA-induced increases in c with IC50=13.4±3.6 µM confirming the inhibition of NMDA receptors observed in electrophysiological experiments. wtRyR1-HEK 293 pretreated with KB-R7943 (10 μM, 10 min) dissolved in the bulk perfusion exhibited significantly attenuated responses to caffeine. In this regard, KB-R7943 produced more pronounced inhibition of caffeine-induced Ca2+ release elicited by 1 mM compared with 0.5 and 0.75 mM (60 versus 58 versus 37%, p. KB-R7943 inhibits both IhERG and native IKr rapidly on membrane depolarization with IC50 values of ~89 and ~120 nM, respectively, for current tails at −40 mV following depolarizing voltage commands to +20 mV. IhERG inhibition by KB-R7943 exhibits both time- and voltage-dependence but shows no preference for inactivated over activated channels. | |
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