JI-101
- JI 101；JI101
货号： abs811363
| 货号-规格 | 货期 | 价格 | 数量 |
| abs811363-5mg | 现货 | ￥1365.00 | - + |
| abs811363-10mg | 现货 | ￥1996.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | JI-101 is an orally active inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor beta (PDGFRb), and the ephrin B4 receptor B4 (EphB4) with potential antiangiogenic and antineoplastic activities. | |
| 纯度 | >98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | JI 101；JI101 | |
| 外观 | Pale Brown Solid | |
| 可溶性/溶解性 | DMSO : ≥ 100 mg/mL (214.44 mM) | |
| 生物活性 | ||
| 靶点 | Ephrin Receptor | |
| In vitro(体外研究) | JI-101 is found to be stable in all preclinical and human liver microsomes. The % metabolized is ranged between 3.03-3.95 across the tested species liver microsomes. The % metabolized is relatively higher in mice liver microsomes followed by dog, human and rat liver microsomes. | |
| In vivo(体内研究) | JI-101excreted through bile along with its mono- and di-hydroxy metabolites. Following oral administration, JI-101 is rapidly absorbed, reaching Cmax within 2 h. The t1/2 of JI-101 with intravenous and oral route is found to be 1.75±0.79 and 2.66±0.13 h, respectively. The Cl and Vd by intravenous route for JI-101 are found to be 13.0±2.62 mL/min/kg and 2.11±1.42 L/kg, respectively. The tissue distribution of JI-101 is extensive with rapid and preferred uptake into lung tissue. Overall, the oral bioavailability of JI-101 is 55% and the primary route of elimination for JI-101 is feces. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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