首页 产品中心
  • ITE

    • Aryl hydrocarbon receptor ligand
    货号: abs814131
    CAS号: 448906-42-1
    分子式: C14H10N2O3S
    分子量: 286.3
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs814131-10mg 1-2周 ¥1418.00
    - +
    abs814131-50mg 现货 ¥4961.00
    - +
    abs814131-100mg 1-2周 ¥7938.00
    - +
    大包装询价
    产品描述
    描述

    ITE is an Endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM).

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    Aryl hydrocarbon receptor ligand
    外观
    Powder
    可溶性/溶解性
    DMSO : ≥ 41 mg/mL (143.20 mM)
    生物活性
    靶点
    Aryl Hydrocarbon Receptor
    In vitro(体外研究)
    ITE is an endogenous agonist of AhR, binding directly to AHR, with a Ki of 3 nM. ITE (0.03-30 mg/mL) decreases the antigen-specific T-cell proliferative responses. ITE potently inhibits human pulmonary artery endothelial (HPAECs) growth at 10 and 20 µM, but shows no effect at 0.01-5 µM. ITE does not affect cell cycle progress of HPAECs at 10 and 20 µM, or induce expression of cleaved caspase-3 protein in HPAECs at 20 µM. In addition, ITE (20 µM) elevates CYP1A1 and CYP1B1 mRNA levels and decreases the levels of AhR protein in HPAECs.
    In vivo(体内研究)
    ITE (200 μg, i.p.) significantly suppresses the development of experimental autoimmune uveitis (EAU) in mice. ITE reduces the proportions of cells expressing IFN-γ, IL-17, or IL-10 in mice. ITE also suppresses the secretion of inflammatory cytokines by LN cells in mice.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
      0张,还能上传 8 提交
          提示: 尊敬的客户您好,如果您对我们的产品有什么疑问或想要了解的,可以点击“我要提问”按钮填写您的疑问。
          提交不成功?请联系info@absin.cn。
          我要提问

      促销资讯 更多

        订购信息
        您可以从我们的授权经销商处购买absin产品或获得技术支持。若要查看您所在地区的经销商,请从以下的下拉列表中选择。
        GO
        • 0