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  • ISO-1
  • MIF Antagonist
  • 货号: abs814764
    CAS号: 478336-92-4
    分子式: C12H13NO4
    分子量: 235.24
    产品说明书
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    货号-规格 货期 价格 数量
    abs814764-5mg 1-2周 ¥893.00
    - +
    abs814764-25mg 1-2周 ¥2625.00
    - +
    大包装询价
    产品描述
    描述

    ISO-1 is an inhibitor of MIF (Macrophage migration inhibitory factor) D-dopachrome tautomerase activity with an IC50 of ~7 μM.

    纯度
    ≥98%
    储存/保存方法
    Store at -20° C
    形态
    Solid
    基本信息
    别名
    MIF Antagonist
    外观
    Light yellow solid
    密度
    ~1.3 g/cm3 (Predicted)
    熔点
    133.69° C (Predicted)
    沸点
    ~337.6° C at 760 mmHg (Predicted)
    折射率
    n20D 1.55 (Predicted)
    IC50
    D-dopachrome tautomerase: IC50 = 7 µM; MIF tautomerase activity: IC50 = 11 µM; spontaneous secretion/release/recognition of MIF: IC50 = 25 µM (human PBMC)
    可溶性/溶解性
    DMSO : ≥ 36 mg/mL (153.04 mM)
    PubChem CID
    6098948
    生物活性
    靶点
    MIF
    In vitro(体外研究)
    ISO-1 significantly inhibits the cytokine activity in vitro. It inhibits tumor necrosis factor release from macrophages isolated from LPStreated wild type mice but has no effect on cytokine release from MIF-deficient macrophages.
    In vivo(体内研究)
    ISO-1 significantly increases the survival rate in severe sepsis induced by endotoxin or cecal ligation and puncture (CLP). It could prevent airway hyperresponsiveness (AHR) in mouse ovalbumin (OVA)-challenge models. ISO-1 attenuated ozone-induced cell recruitment, cytokine release and AHR in the mouse but did not affect measures of emphysema. ISO-1 protects photoreceptors and reduces gliosis in experimental retinal detachment.
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