ISO-1
- MIF Antagonist
货号: abs814764
货号-规格 | 货期 | 价格 | 数量 |
abs814764-10mg | 1-2周 | ¥915.00 | - + |
abs814764-50mg | 1-2周 | ¥2745.00 | - + |

产品描述 | ||
描述 | ISO-1 is an inhibitor of MIF (Macrophage migration inhibitory factor) D-dopachrome tautomerase activity with an IC50 of ~7 μM. | |
纯度 | ≥98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
形态 | Solid | |
基本信息 | ||
别名 | MIF Antagonist | |
外观 | Light yellow solid | |
密度 | ~1.3 g/cm3 (Predicted) | |
熔点 | 133.69° C (Predicted) | |
沸点 | ~337.6° C at 760 mmHg (Predicted) | |
折射率 | n20D 1.55 (Predicted) | |
IC50 | D-dopachrome tautomerase: IC50 = 7 µM; MIF tautomerase activity: IC50 = 11 µM; spontaneous secretion/release/recognition of MIF: IC50 = 25 µM (human PBMC) | |
可溶性/溶解性 | DMSO :47 mg/mL (199.80 mM) | |
PubChem CID | 6098948 | |
生物活性 | ||
靶点 | MIF | |
In vitro(体外研究) | ISO-1 significantly inhibits the cytokine activity in vitro. It inhibits tumor necrosis factor release from macrophages isolated from LPStreated wild type mice but has no effect on cytokine release from MIF-deficient macrophages. | |
In vivo(体内研究) | ISO-1 significantly increases the survival rate in severe sepsis induced by endotoxin or cecal ligation and puncture (CLP). It could prevent airway hyperresponsiveness (AHR) in mouse ovalbumin (OVA)-challenge models. ISO-1 attenuated ozone-induced cell recruitment, cytokine release and AHR in the mouse but did not affect measures of emphysema. ISO-1 protects photoreceptors and reduces gliosis in experimental retinal detachment. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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