ISO-1

≥98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

Solid

MIF Antagonist

Light yellow solid

~1.3 g/cm³ (Predicted)

133.69° C (Predicted)

~337.6° C at 760 mmHg (Predicted)

n²⁰_D 1.55 (Predicted)

D-dopachrome tautomerase: IC₅₀ = 7 µM; MIF tautomerase activity: IC₅₀ = 11 µM; spontaneous secretion/release/recognition of MIF: IC₅₀ = 25 µM (human PBMC)

DMSO ：47 mg/mL (199.80 mM)

6098948

MIF

ISO-1 significantly inhibits the cytokine activity in vitro. It inhibits tumor necrosis factor release from macrophages isolated from LPStreated wild type mice but has no effect on cytokine release from MIF-deficient macrophages.

ISO-1 significantly increases the survival rate in severe sepsis induced by endotoxin or cecal ligation and puncture (CLP). It could prevent airway hyperresponsiveness (AHR) in mouse ovalbumin (OVA)-challenge models. ISO-1 attenuated ozone-induced cell recruitment, cytokine release and AHR in the mouse but did not affect measures of emphysema. ISO-1 protects photoreceptors and reduces gliosis in experimental retinal detachment.