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  • ISCK03

    • N-(4-imidazol-1-yl phenyl)sulfonamide
    货号: abs819913
    CAS号: 945526-43-2
    分子式: C19H21N3O2S
    分子量: 355.45
    产品说明书
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    货号-规格 货期 价格 数量
    abs819913-10mg 1-2周 ¥900.00
    - +
    abs819913-50mg 1-2周 ¥3200.00
    - +
    大包装询价
    产品描述
    描述
    ISCK03 is a specific SCF/c-Kit inhibitor.
    纯度
    ≥98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    N-(4-imidazol-1-yl phenyl)sulfonamide
    外观
    yellow solid
    可溶性/溶解性
    DMSO:71 mg/mL (199.75 mM)
    Ethanol:3 mg/mL (8.44 mM)
    生物活性
    靶点
    SCF;c-Kit
    In vitro(体外研究)
    Pretreatment of 501mel cells with ISCK03 inhibits SCF-induced c-kit phosphorylation dose dependently. ISCK03 also inhibits p44/42 ERK mitogen-activated protein kinase (MAPK) phosphorylation, which is known to be involved in SCF/c-kit downstream signaling. However ISCK03 does not inhibit hepatocyte growth factor (HGF)-induced phosphorylation of p44/42 ERK proteins. ISCK03, a tyrosine kinase inhibitor specific to KIT, prevents survival of CCDC26-KD cells under low-serum conditions. All treated cells exhibits sensitivity to ISCK03 in a dose-dependent manner. After ISCK03 treatment, the survival of KD cells is suppressed to the same level as that of non-KD cells. Conversely, ISCK03 treatment has limited effects on the growth of control K562 and KD clone 3–4 cells under high-serum concentration conditions.
    In vivo(体内研究)
    Oral administration of ISCK03 induces the dose-dependent depigmentation of newly regrown hair, and this is reversed with cessation of ISCK03 treatment. The topical application of ISCK03 promotes the depigmentation of UV-induced hyperpigmented spots. Fontana-Masson staining analysis shows epidermal melanin is diminished in spots treated with ISCK03.
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    • 实验方法 实验条件
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