ISCK03
- N-(4-imidazol-1-yl phenyl)sulfonamide
货号: abs819913
货号-规格 | 货期 | 价格 | 数量 |
abs819913-10mg | 1-2周 | ¥900.00 | - + |
abs819913-50mg | 1-2周 | ¥3200.00 | - + |

产品描述 | ||
描述 | ISCK03 is a specific SCF/c-Kit inhibitor. | |
纯度 | ≥98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | N-(4-imidazol-1-yl phenyl)sulfonamide | |
外观 | yellow solid | |
可溶性/溶解性 | DMSO:71 mg/mL (199.75 mM) Ethanol:3 mg/mL (8.44 mM) | |
生物活性 | ||
靶点 | SCF;c-Kit | |
In vitro(体外研究) | Pretreatment of 501mel cells with ISCK03 inhibits SCF-induced c-kit phosphorylation dose dependently. ISCK03 also inhibits p44/42 ERK mitogen-activated protein kinase (MAPK) phosphorylation, which is known to be involved in SCF/c-kit downstream signaling. However ISCK03 does not inhibit hepatocyte growth factor (HGF)-induced phosphorylation of p44/42 ERK proteins. ISCK03, a tyrosine kinase inhibitor specific to KIT, prevents survival of CCDC26-KD cells under low-serum conditions. All treated cells exhibits sensitivity to ISCK03 in a dose-dependent manner. After ISCK03 treatment, the survival of KD cells is suppressed to the same level as that of non-KD cells. Conversely, ISCK03 treatment has limited effects on the growth of control K562 and KD clone 3–4 cells under high-serum concentration conditions. | |
In vivo(体内研究) | Oral administration of ISCK03 induces the dose-dependent depigmentation of newly regrown hair, and this is reversed with cessation of ISCK03 treatment. The topical application of ISCK03 promotes the depigmentation of UV-induced hyperpigmented spots. Fontana-Masson staining analysis shows epidermal melanin is diminished in spots treated with ISCK03. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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