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  • Irbinitinib(ARRY-380; ONT-380)

    货号: abs817502
    CAS号: 937263-43-9
    分子式: C26H24N8O2
    分子量: 480.52
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs817502-5mg 1-2周 ¥1074.00
    - +
    abs817502-10mg 1-2周 ¥1892.00
    - +
    abs817502-50mg 1-2周 ¥7567.00
    - +
    大包装询价
    产品描述
    描述
    Irbinitinib(ARRY-380; ONT-380) is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR.
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    可溶性/溶解性
    10 mM in DMSO
    生物活性
    靶点
    p95 HER2 ,ErbB2
    In vitro(体外研究)
    The compound is a reversible, ATP-competitive inhibitor with nanomolar potency against ErbB2 in both in vitro and in cell-based assays. Incell-based assays, ARRY-380 is ~500-fold selective for HER2 vs. EGFR and is equipotent against truncated p95-HER2.
    In vivo(体内研究)
    In vivo, ARRY-380 significantly inhibits tumor growth in multiple HER2-dependent tumor xenograft models. It shows excellent activity in numerous mouse tumor models including breast (BT-474, MDA-MB-453), ovarian (SKOV-3) and gastric (N87) carcinoma models. In the BT-474 model, ARRY-380 demonstrated significant dose-related tumor growth inhibition (TGI; 50% at 50 mg/kg/d and 96% at 100 mg/kg/d) with numerous partial regressions (>50% reduction from baseline size).
    参考文献
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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