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  • INNO-206
  • 货号: abs818801
    CAS号: 1361644-26-9
    分子式: C37H42N4O13
    分子量: 750.75
    产品说明书
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    货号-规格 货期 价格 数量
    abs818801-2mg 1-2周 ¥1512.00
    - +
    abs818801-5mg 1-2周 ¥2268.00
    - +
    大包装询价
    产品描述
    描述
    Aldoxorubicin (INNO-206) is an albumin-binding prodrug of doxorubicin, which is released from albumin under acidic conditions. Aldoxorubicin (INNO-206) has potent antitumor activities in various cancer cell lines and in murine tumor models.
    基本信息
    可溶性/溶解性
    10 mM in DMSO
    生物活性
    靶点
    ADC Cytotoxin
    In vivo(体内研究)
    INNO-206 (10.8 mg/kg, i.v.) shows significantly smaller tumor volumes and IgG levels on days 28, and is well tolerated with 90% of mice surviving until the termination of the study in the mice bearing the LAGκ-1A tumor. INNO-206 shows a good safety profile at doses up to 260 mg/mL doxorubicin equivalents, and is able to induce tumor regressions in breast cancer, small cell lung cancer and sarcoma in phase I study. INNO-206 shows superior activity over doxorubicin in a murine renal cell carcinoma model and in breast carcinoma xenograft models.
    参考文献
    参考文献
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