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  • Indomethacin

    • 吲哚美辛;Indometacin
    货号: abs817976
    CAS号: 53-86-1
    分子式: C19H16ClNO4
    分子量: 357.79
    产品说明书
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    货号-规格 货期 价格 数量
    abs817976-50mg 现货 ¥331.00
    - +
    abs817976-200mg 1-2周 ¥827.00
    - +
    abs817976-500mg 1-2周 ¥1158.00
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    大包装询价
    产品描述
    描述

    Indomethacin是非甾体抗炎化合物,可作用于发烧,肿胀和疼痛等。

    纯度
    99%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    吲哚美辛;Indometacin
    外观
    White to off-white powder
    可溶性/溶解性
    DMSO : 35.8 mg/mL (100 mM)
    Ethanol : 17.9 mg/mL (50 mM), with gentle warming
    生物活性
    靶点
    COX1 ,COX-2
    In vitro(体外研究)
    Indomethacin inhibits transcription of a beta-catenin/TCF-responsive reporter gene in a dose dependent manner. Indomethacin also downregulates the beta-catenin/TCF transcriptional target cyclin D1. Indomethacin attenuates the transcription of beta-catenin/TCF-responsive genes, by modulating TCF activity without disrupting beta-catenin/TCF complex formation.
    In vivo(体内研究)
    Indomethacin increases BrdU+ cells of all lineages and reduces microglial/monocyte activation in rats after focal cerebral ischemia. Indomethacin (7.5 mg/kg, one injection) produces acute injury and inflammation in the distal jejunum and proximal ileum that are maximal at three days and completely resolves within one week. Indomethacin (two daily subcutaneous injections) produces a more extensive and chronic inflammation that lasts in an active form in more than 75% of the rats for at least two weeks. Indomethacin (4ppm) reduces tumor yield by 78% in SKH:HR-1-hrBr hairless mice. Indomethacin (20 mg/kg, orally) increases the total area of gastric erosions and concentration of lipid peroxides in the gastric mucosa of rats. Indomethacin increases the alpha-tocopherol:total cholesterol ratio in serum. Indomethacin inhibits the increases in gastric mucosal erosions and lipid peroxides in the gastric mucosa, and the reduction of serum alpha-tocopherol.
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