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  • Recombinant Mouse IL-1 Receptor Antagonist Protein/IL-1ra/IL-1RA
  • IL-1RN/IL-1ra/IRAP/IL1 inhibitor/Il1rn
  • 货号: abs04471
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs04471-10ug 1-2周 ¥1260.00
    - +
    abs04471-50ug 1-2周 ¥3696.00
    - +
    abs04471-500ug 1-2周 ¥12936.00
    - +
    abs04471-1mg 1-2周 ¥17600.00
    - +
    大包装询价
    概述
    描述
    Recombinant Mouse Interleukin-1 Receptor Antagonist Protein is produced by our E.coli expression system and the target gene encoding Arg27-Gln178 is expressed.
    别名
    IL-1RN/IL-1ra/IRAP/IL1 inhibitor/Il1rn
    来源
    Escherichia coli.
    形态
    Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
    性能
    氨基酸序列
    MRPSGKRPCKMQAFRIWDTNQKTFYLRNNQLIAGYLQGPNIKLEEKIDMVPIDLHSVFLGIHGGK LCLSCAKSGDDIKLQLEEVNITDLSKNKEEDKRFTFIRSEKGPTTSFESAACPGWFLCTTLEADR PVSLTNTPEEPLIVTKFYFQEDQ
    纯度
    Greater than 95% as determined by reducing SDS-PAGE.
    内毒素水平
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.
    溶解方法
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    靶标
    背景说明
    Interleukin-1 receptor antagonist protein (Il1rn), also known as IL-1ra, IRAP or IL1 inhibitor, is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. The mouse Il1rn gene encodes a 178 amino acids (aa) protein with a 26 aa signal peptide. Mouse Il1rn protein shares 26% and 19% identity with its homologues IL-1 beta and IL-1 alpha, respectively. Il1rn can Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling, but has no interleukin-1 like activity. Recently, an recombinant human Il1rn protein is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role.
    Accession
    P25085
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