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  • Recombinant Mouse Indoleamine 2,3-Dioxygenase/IDO/INDO (N-6His)
  • Indole 2,3-dioxygenase, Indoleamine 2,3-dioxygenase 1, IDO-1, IDO1, IDO, INDO
  • 货号: abs04531
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs04531-10ug 1-2周 ¥1260.00
    - +
    abs04531-50ug 1-2周 ¥3696.00
    - +
    abs04531-500ug 1-2周 ¥14112.00
    - +
    abs04531-1mg 1-2周 ¥19200.00
    - +
    大包装询价
    概述
    描述
    Recombinant Mouse Indoleamine 2,3-dioxygenase is produced by our E.coli expression system and the target gene encoding Met1-Pro407 is expressed with a 6His tag at the N-terminus.
    别名
    Indole 2,3-dioxygenase, Indoleamine 2,3-dioxygenase 1, IDO-1, IDO1, IDO, INDO
    来源
    Escherichia coli.
    形态
    Supplied as a 0.2 μm filtered solution of 20mM Sodium Acetate, 150mM NaCl and 20% Glycerol, pH4.5..
    性能
    氨基酸序列
    MNHKVHHHHHHMALSKISPTEGSRRILEDHHIDEDVGFALPHPLVELPDAYSPWVLVARNLPVLI ENGQLREEVEKLPTLSTDGLRGHRLQRLAHLALGYITMAYVWNRGDDDVRKVLPRNIAVPYCELS EKLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLVSLLVEIAASPAIKA IPTVSSAVERQDLKALEKALHDIATSLEKAKEIFKRMRDFVDPDTFFHVLRIYLSGWKCSSKLPE GLLYEGVWDTPKMFSGGSAGQSSIFQSLDVLLGIKHEAGKESPAEFLQEMREYMPPAHRNFLFFL ESAPPVREFVISRHNEDLTKAYNECVNGLVSVRKFHLAIVDTYIMKPSKKKPTDGDKSEEPSNVE SRGTGGTNPMTFLRSVKDTTEKALLSWP
    纯度
    Greater than 95% as determined by reducing SDS-PAGE.
    内毒素水平
    Less than 0.1 ng/?g (1 IEU/?g) as determined by LAL test.
    靶标
    背景说明
    Indoleamine 2,3-dioxygenase (IDO) is a heme enzyme that initiates the oxidative degradation of the least abundant, essential amino acid, l-tryptophan, along the kynurenine pathway. This protein is normally expressed in the dendritic cells, macrophages, microglia, eosinophils, fibroblasts, endothelial cells, and most tumor cells. IDO activity is associated with immunosuppression and immune attenuation. Several studies showed that IDO can contribute to immune escape when expressed directly in tumor cells or when expressed in immunosuppressive antigen presenting cells such as tolerogenic dendritic cells or tumor associated macrophages. IDO also is a promising therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterized by pathological immune suppression.
    Accession
    P28776
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