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  • Ibutamoren Mesylate
    • 伊布莫仑甲磺酸盐;MK-677;Crescendo; MK 0677;MK-0677;MK0677;MK677;MK 677
    货号: abs810362
    CAS号: 159752-10-0
    分子式: C28H40N4O8S2
    分子量: 624.77
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810362-10mg 1-2周 ¥827.00
    - +
    abs810362-50mg 1-2周 ¥2867.00
    - +
    abs810362-100mg 1-2周 ¥4300.00
    - +
    大包装询价
    产品描述
    描述

    Ibutamoren mesylate (MK-0677) is an orally active nonpeptide growth hormone (GH) secretagogue.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    伊布莫仑甲磺酸盐;MK-677;Crescendo; MK 0677;MK-0677;MK0677;MK677;MK 677
    外观
    white to beige Powder
    可溶性/溶解性
    Water : ≥ 50 mg/mL (80.03 mM)
    DMSO : 50 mg/mL (80.03 mM; Need ultrasonic)
    生物活性
    靶点
    GHSR
    In vivo(体内研究)
    Ibutamoren mesylate (5 mg/kg/day) results in a statistically significant increases body weight gain and increases serum IGF-1 and GH levels in dogs. Ibutamoren mesylate results in no significant increase in CSF IGF-1 or GH levels on days 7 or 15 of the study. Pretreating mice with GH blocks activation of these neurons by Ibutamoren mesylate (50 μg, i.p.). In the knockout mice, both GH and octreotide fail to inhibit Ibutamoren mesylate activation of arcuate neurons. Chronic oral administration of MK-0677 is associated with significant increases in GH and IGF-I levels that are maintained for the duration of the treatment. The GH profile following MK-0677 administration consists of episodic increases above control. MK-0677 significantly increases peak GH concentrations after oral administration. MK-0677 is a potent GH secretagogue that induces an immediate, large, long lasting increase in GH levels when administered orally or i.v.
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