HQL-79

HQL-79 is a selective inhibitor of PGD (hematopoietic prostaglandin D) synthase (PGE synthase). It is a synthetic tetrazole compound originally prepared as a possible antihistamine. Subsequent evaluation in models of allergy and asthma demonstrates the HQL-79 inhibits the synthesis of PGD2. HQL-79 is thus a likely lead compound for the preparation of potent, selective PGE synthase inhibitors.

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

white to beige powder

Soluble in methanol (~2.5 mg/ml), PBS (pH 7.2), and DMSO (25 mM). Insoluble in water at 25° C.

HQL-79 is a competitive inhibitor against substrate PGH2 and a non-competitive one against GSH.