HM-30181-A
- Encequidar;HM30181;HM30181A
货号: abs813092
货号-规格 | 货期 | 价格 | 数量 |
abs813092-5mg | 1-2周 | ¥1158.00 | - + |
abs813092-10mg | 1-2周 | ¥1709.00 | - + |
abs813092-50mg | 1-2周 | ¥5237.00 | - + |

产品描述 | ||
描述 | HM-30181-A是一种有效的选择性的P-glycoprotein抑制剂。 | |
纯度 | 98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | Encequidar;HM30181;HM30181A | |
可溶性/溶解性 | DMSO : 2.4 mg/mL (3.48 mM; Need ultrasonic) | |
生物活性 | ||
靶点 | P-glycoprotein | |
In vitro(体外研究) | HM30181 is shown to be approximately equipotent with the reference Pgp inhibitor tariquidar in inhibiting rhodamine 123 efflux from CCRF-CEM T cells (IC50, tariquidar: 8.2±2.0 nM, HM30181: 13.1±2.3 nM) . HM30181 shows a high selectivity for mP-gp and its potency is 20-50 times higher than that of tariquitar, another third generation P-gp inhibitor. | |
In vivo(体内研究) | PET scans with the Pgp substrate (R)-verapamil in FVB wild-type mice pretreated i.v. with HM30181 (10 or 21 mg/kg) failes to show significant increases in (R)-verapamil brain uptake compared with vehicle treated animals. HM30181 inhibits P-gp mainly in the intestinal endothelium, which can be beneficial because pan-inhibition of P-gp, particularly in the brain, could lead to detrimental adverse events. HM30181 increases the oral bioavailability of co-administered paclitaxel by more than 12 times in rats. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
共 0 张,还能上传 8 张 提交
- 提示: 尊敬的客户您好,如果您对我们的产品有什么疑问或想要了解的,可以点击“我要咨询”按钮填写您的疑问。
提交不成功?请联系info@absin.cn。
促销资讯 更多
订购信息
您可以从我们的授权经销商处购买absin产品或获得技术支持。若要查看您所在地区的经销商,请从以下的下拉列表中选择。