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  • Histamine
    • 组胺;Ergamine
    货号: abs816982
    CAS号: 51-45-6
    分子式: C5H9N3
    分子量: 111.15
    产品说明书
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    货号-规格 货期 价格 数量
    abs816982-10mg 现货 ¥440.00
    - +
    abs816982-50mg 1-2周 ¥673.00
    - +
    abs816982-100mg 现货 ¥1043.00
    - +
    大包装询价
    产品描述
    描述

    Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.

    纯度
    ≥98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    组胺;Ergamine
    外观
    白色或淡黄色结晶粉末
    可溶性/溶解性
    Ethanol : Soluble

    Water : ≥34 mg/mL
    生物活性
    靶点
    Histamine Receptor
    In vitro(体外研究)
    Histamine stimulates the proliferation of human articular chondrocytes in culture. Histamine is reported to modify the behaviour of many cell types in vitro, including chondrocytes, fibroblasts, macrophages, epithelial cells, endothelial cells, and T cells. Histamine also modulates the production of many cytokines and the expression of their receptors. Histamine regulates cellular processes through the expression of histamine receptors. Histamine stimulates the production of matrix metalloproteinases (MMPs)-13 and -3 (collagenase 3 and stromelysin-1, respectively) by histidine decarboxylase (HAC) in vitro.
    In vivo(体内研究)
    Histamine has a recognised role in allergic and inflammatory reactions and is an important modulator of numerous physiological processes, including cell proliferation, angiogenesis, and vasopermeability. Histamine dilates vasculature, increases blood flow, while it induces hyperpermeability in venula. It disrupts endothelial barrier formation of venula indicated by changes in vascular endothelial cadherin (VE-cadherin) localization at endothelial cell junction.
    参考文献
    参考文献
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