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  • Harmine

    • 肉叶云香碱;去氢骆驼蓬碱;哈尔明碱;Telepathine
    货号: abs822133
    CAS号: 442-51-3
    分子式: C13H12N2O
    分子量: 212.25
    产品说明书
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    货号-规格 货期 价格 数量
    abs822133-500mg 1-2周 ¥662.00
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    大包装询价
    产品描述
    描述
    Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase ((DYRK)) inhibitor with anticancer and anti-inflammatory activities.
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    肉叶云香碱;去氢骆驼蓬碱;哈尔明碱;Telepathine
    外观
    White to off-white Powder
    可溶性/溶解性
    DMSO : 12.5 mg/mL (58.89 mM; Need ultrasonic)
    生物活性
    In vitro(体外研究)
    Harmine inhibits tau phosphorylation by DYRK1A by selected DANDYs, with an IC50 of 190 nM.Harmine negatively regulates homologous recombination (HR) by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine.
    In vivo(体内研究)
    It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine treatment. The neuronal survival rate in the Harmine-treated group is significantly increased, compared with the TBI group. Administration of Harmine results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine significantly reduces the expression of caspase 3, compared with the TBI group.
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