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  • GW-9662

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    • GW9662; GW 9662; TIMTEC-BB SBB006523
    货号: abs810411
    CAS号: 22978-25-2
    分子式: C13H9ClN2O3
    分子量: 276.68
    产品说明书
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    货号-规格 货期 价格 数量
    abs810411-5mg 现货 ¥603.00 ¥181.00
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    abs810411-50mg 现货 ¥2255.00 ¥677.00
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    大包装询价
    产品描述
    描述

    GW9662 is a selective PPAR antagonist, inhibiting PPARγ, PPARα and PPARδ with IC50 of 3.3 nM, 32 nM and 2 μM, respectively.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    GW9662; GW 9662; TIMTEC-BB SBB006523
    外观
    白色固体
    可溶性/溶解性
    DMSO : 27.7 mg/mL (100 mM)

    Ethanol : 6.9 mg/mL (25 mM), with gentle warming






    生物活性
    靶点
    PPARγ ,PPARα
    In vitro(体外研究)
    GW9662 binds to Cys(285) on PPARgamma which is conserved among all three PPARs. GW9662 acts as an antagonist of PPARgamma which is confirmed in an assay of adipocyte differentiation inhibition. GW9662 prevents activation of PPARγ and inhibits growth of human mammary tumour cell lines (MCF7, MDA-MB-468, MDA-MB-231) with IC50 of 20 μM-30 μM, suggesting either the existence of PPARγ agonistic properties of GW9662 or growth-inhibitory mechanisms independent of PPARγ. Co-treatment with both Rosiglitazone (50 μM) and GW9662 (10 μM) results in statistically lower viable cell numbers after 7 days in MDA-MB-231 cells. PPARγ1 ligands could suppress RANKL-induced osteoclast formation in primary murine myeloid (BMs) and RAW264.7 cells. Importantly, suppression by these ligands is reversed in a concentration-dependent fashion with GW 9662 (2 μM). GW 9662 (2 μM) blocks IL-4 suppression of osteoclast formation in BMs. GW 9662 (1 μM) blocks RANKL activation of NF-κB in RAW264.7 cells. GW9662 (10 μM) inhibits hormone- and agonist-induced adipogenesis of primary preadipocytes from patients with thyroid eye disease.
    In vivo(体内研究)
    Pretreatment with LPS (1 mg/kg i.p.) significantly attenuates all markers of renal injury and dysfunction caused by ischemia/reperfusion (I/R) injury in rats. Most notably, GW9662 (1 mg/kg i.p.) abolishes the protective effects of LPS.
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    • 实验方法 实验条件
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