GSK2578215A
货号： abs817453
| 货号-规格 | 货期 | 价格 | 数量 |
| abs817453-5mg | 1-2周 | ￥663.00 | - + |
| abs817453-10mg | 1-2周 | ￥919.00 | - + |
| abs817453-50mg | 1-2周 | ￥3152.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | GSK2578215A is a potent and selective LRRK2 kinase inhibitor with IC50 of 8.9 nM and 10.9 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively. | |
| 纯度 | 99% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 可溶性/溶解性 | 200 mM in DMSO | |
| 生物活性 | ||
| 靶点 | LRRK2 (G2019S),LRRK2 (WT) | |
| In vitro(体外研究) | GSK2578215A induces a dose-dependent inhibition of Ser910 and Ser935 phosphorylation in both wild-type LRRK2 and LRRK2 stably transfected into HEK293 cells, and induces similar dose-dependent Ser910 and Ser935 dephosphorylation of endogenous LRRK2 in mouse Swiss 3T3 cells. In SH-SY5Y cells, GSK2578215A impairs the autophagy flux by altering autophagosome–lysosome fusion, and induces mitophagy though induction of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling. | |
| In vivo(体内研究) | In vivo, GSK2578215A (100 mg/kg i.p.) inhibits Ser910 and Ser935 phosphorylation in mouse spleen and kidney, but not in brain. | |
| 参考文献 | ||
| 参考文献 | ||
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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Certificate of Analysis(COA)
