GSK2578215A
货号: abs817453
货号-规格 | 货期 | 价格 | 数量 |
abs817453-5mg | 1-2周 | ¥663.00 | - + |
abs817453-10mg | 1-2周 | ¥919.00 | - + |
abs817453-50mg | 1-2周 | ¥3152.00 | - + |

产品描述 | ||
描述 | GSK2578215A is a potent and selective LRRK2 kinase inhibitor with IC50 of 8.9 nM and 10.9 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively. | |
纯度 | 99% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
可溶性/溶解性 | 200 mM in DMSO | |
生物活性 | ||
靶点 | LRRK2 (G2019S),LRRK2 (WT) | |
In vitro(体外研究) | GSK2578215A induces a dose-dependent inhibition of Ser910 and Ser935 phosphorylation in both wild-type LRRK2 and LRRK2 stably transfected into HEK293 cells, and induces similar dose-dependent Ser910 and Ser935 dephosphorylation of endogenous LRRK2 in mouse Swiss 3T3 cells. In SH-SY5Y cells, GSK2578215A impairs the autophagy flux by altering autophagosome–lysosome fusion, and induces mitophagy though induction of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling. | |
In vivo(体内研究) | In vivo, GSK2578215A (100 mg/kg i.p.) inhibits Ser910 and Ser935 phosphorylation in mouse spleen and kidney, but not in brain. | |
参考文献 | ||
参考文献 | ||
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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