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  • GSK2033
    • LXR antagonist 2033
    货号: abs820371
    CAS号: 1221277-90-2
    分子式: C29H28F3NO5S2
    分子量: 591.66
    产品说明书
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    货号-规格 货期 价格 数量
    abs820371-5mg 4周 ¥1455.00
    - +
    abs820371-25mg 4周 ¥5557.00
    - +
    大包装询价
    产品描述
    描述
    GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα or LXRβ, respectively.
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    LXR antagonist 2033
    外观
    white to beige powder
    可溶性/溶解性
    DMSO : 30 mg/mL (50.70 mM; Need ultrasonic and warming)
    生物活性
    In vitro(体外研究)
    GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα or LXRβ, respectively. GSK2033 dose-dependently suppresses basal transcription in full-length LXRα or full-length LXRβ cotransfection assays with IC50s of 17 nM and 9 nM, respectively. GSK2033 also effectively suppresses the transcription of an ABCA1 driven luciferase reporter dose-dependently displaying IC50s of 52 nM for LXRα and 10 nM for LXRβ. GSK2033 also suppresses the expression of both of fatty acid synthase (FASN) and SREBP1.
    In vivo(体内研究)
    One month treatment of GSK2033 does not have significant effects on hepatic triglyceride levels. Plasma triglyceride levels are also unaffected by treatment with GSK2033.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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