货号： abs810803
| 货号-规格 | 货期 | 价格 | 数量 |
| abs810803-5mg | 1-2周 | ￥748.00 | - + |
| abs810803-10mg | 1-2周 | ￥950.00 | - + |
| abs810803-50mg | 1-2周 | ￥3057.00 | - + |
| abs810803-100mg | 1-2周 | ￥5502.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | BPTES is a selective inhibitor of Glutaminase GLS1 (KGA) | |
| 纯度 | >98% | |
| 储存/保存方法 | store at -20℃ for one year（Powder）；
in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. | |
| 基本信息 | ||
| 外观 | Powder | |
| 可溶性/溶解性 | DMSO：100 mg/mL warmed (190.59 mM) | |
| 生物活性 | ||
| 靶点 | Glutaminase GLS1 (KGA) | |
| In vitro(体外研究) | BPTES inhibits glutaminase activity expressed in human kidney cells with IC50 of 0.18 μM, and inhibits glutamate efflux by microglia with IC50 of 80-120 nM. BPTES preferentially slows cell growth in D54 cells with mutant IDH1. BPTES also inhibits glutaminase activity, lowers glutamate and α-KG levels, and increases glycolytic intermediates. BPTES (10 μM) inhibits cell growth of mHCC 3–4 cells derived from LAP/MYC tumors. BPTES also inhibits growth of a MYC-dependent P493 cells by blocking DNA replication, leading to cell death and fragmentation. | |
| In vivo(体内研究) | In LAP/MYC mice, BPTES (12.5 mg/kg, i.p.) prolongs survival with no significant effects on MYC, GLS, or GLS2 levels. BPTES (200 μg/mouse, i.p.) also inhibits tumor cell growth in mice harboring P493 tumor xenografts. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
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Certificate of Analysis(COA)
