货号: abs810803
货号-规格 | 货期 | 价格 | 数量 |
abs810803-5mg | 1-2周 | ¥748.00 | - + |
abs810803-10mg | 1-2周 | ¥950.00 | - + |
abs810803-50mg | 1-2周 | ¥3057.00 | - + |
abs810803-100mg | 1-2周 | ¥5502.00 | - + |

产品描述 | ||
描述 | BPTES is a selective inhibitor of Glutaminase GLS1 (KGA) | |
纯度 | >98% | |
储存/保存方法 | store at -20℃ for one year(Powder);
in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. | |
基本信息 | ||
外观 | Powder | |
可溶性/溶解性 | DMSO:100 mg/mL warmed (190.59 mM) | |
生物活性 | ||
靶点 | Glutaminase GLS1 (KGA) | |
In vitro(体外研究) | BPTES inhibits glutaminase activity expressed in human kidney cells with IC50 of 0.18 μM, and inhibits glutamate efflux by microglia with IC50 of 80-120 nM. BPTES preferentially slows cell growth in D54 cells with mutant IDH1. BPTES also inhibits glutaminase activity, lowers glutamate and α-KG levels, and increases glycolytic intermediates. BPTES (10 μM) inhibits cell growth of mHCC 3–4 cells derived from LAP/MYC tumors. BPTES also inhibits growth of a MYC-dependent P493 cells by blocking DNA replication, leading to cell death and fragmentation. | |
In vivo(体内研究) | In LAP/MYC mice, BPTES (12.5 mg/kg, i.p.) prolongs survival with no significant effects on MYC, GLS, or GLS2 levels. BPTES (200 μg/mouse, i.p.) also inhibits tumor cell growth in mice harboring P493 tumor xenografts. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
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