首页 产品中心
  • Glutaminase Inhibitor II, BPTES
    货号: abs810803
    CAS号: 314045-39-1
    分子式: C24H24N6O2S3
    分子量: 524.68
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810803-5mg 1-2周 ¥748.00
    - +
    abs810803-10mg 1-2周 ¥950.00
    - +
    abs810803-50mg 1-2周 ¥3057.00
    - +
    abs810803-100mg 1-2周 ¥5502.00
    - +
    大包装询价
    产品描述
    描述
    BPTES is a selective inhibitor of Glutaminase GLS1 (KGA)
    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    外观
    Powder
    可溶性/溶解性
    DMSO:100 mg/mL warmed (190.59 mM)
    生物活性
    靶点
    Glutaminase GLS1 (KGA)
    In vitro(体外研究)
    BPTES inhibits glutaminase activity expressed in human kidney cells with IC50 of 0.18 μM, and inhibits glutamate efflux by microglia with IC50 of 80-120 nM. BPTES preferentially slows cell growth in D54 cells with mutant IDH1. BPTES also inhibits glutaminase activity, lowers glutamate and α-KG levels, and increases glycolytic intermediates. BPTES (10 μM) inhibits cell growth of mHCC 3–4 cells derived from LAP/MYC tumors. BPTES also inhibits growth of a MYC-dependent P493 cells by blocking DNA replication, leading to cell death and fragmentation.
    In vivo(体内研究)
    In LAP/MYC mice, BPTES (12.5 mg/kg, i.p.) prolongs survival with no significant effects on MYC, GLS, or GLS2 levels. BPTES (200 μg/mouse, i.p.) also inhibits tumor cell growth in mice harboring P493 tumor xenografts.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
        提示: 尊敬的客户您好,如果您对我们的产品有什么疑问或想要了解的,可以点击“我要提问”按钮填写您的疑问。
        提交不成功?请联系info@absin.cn。
        我要提问

    促销资讯 更多

      订购信息
      您可以从我们的授权经销商处购买absin产品或获得技术支持。若要查看您所在地区的经销商,请从以下的下拉列表中选择。
      GO
      • 0