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  • Furosemide sodium

    • 呋塞米钠
    货号: abs819172
    CAS号: 41733-55-5
    分子式: C12H10ClN2NaO5S
    分子量: 352.73
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    货号-规格 货期 价格 数量
    abs819172-500mg 1-2周 ¥1440.00
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    abs819172-1g 1-2周 ¥2440.00
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    大包装询价
    产品描述
    描述

    Furosemide sodium is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema.

    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    呋塞米钠
    可溶性/溶解性
    DMSO : ≥ 150 mg/mL (425.25 mM)
    生物活性
    靶点
    NKCC
    In vitro(体外研究)
    Furosemide sodium (500 µM; 72-96 hours) significantly changes the proliferation rates in MKN45 cells (the poorly differentiated human gastric adenocarcinoma cell line). however, it has no effects on MKN28 cells (the moderately differentiated human gastric adenocarcinoma cell line). The growth rate of MKN45 cells is larger than that of MKN28 cells. Furosemide sodium (10 µM, 30 µM, 100 µM; 45 min exposure)significantly decreases cation channel activity and [Ca(2+)](i) in human erythrocytes drawn from healthy individuals. Tert-butylhydroperoxide similarly enhances the non-selective cation channels activity, increases [Ca(2+)](i) and triggered cell membrane scrambling, however, the effects is significantly blunted by Furosemide sodium again.
    In vivo(体内研究)
    Furosemide sodium (intraperitoneal injection; 100 mg/kg; single dose) is injected after kanamycin (KM) (1000 mg/kg) to creat a deaf mouse model in C57BL/6 mouse. After injection, hearing loss and cochlear hair cell damage are evaluated on day 1, day 2 and day 3, respectively. The hearing is markedly deteriorated even from the next day (Day-1 group), OHCs (outer hair cell) morphology of apical, middle and basal turns are disorganized in mice on day3.
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