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  • Formestane
    • 福美司坦
    货号: abs816290
    CAS号: 566-48-3
    分子式: C19H26O3
    分子量: 302.41
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    货号-规格 货期 价格 数量
    abs816290-50mg 1-2周 ¥669.00
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    abs816290-100mg 1-2周 ¥1004.00
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    abs816290-200mg 1-2周 ¥1405.00
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    大包装询价
    产品描述
    描述

    Formestane (Lentaron (R)) is a second generation selective aromatase inhibitor with an IC50 of 80 nM. Formestane (Lentaron (R)) is used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women. Formestane (Lentaron (R)) is often used to suppress estrogen production from anabolic steroids or prohormones. Formestane (Lentaron (R)) also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a mild aromatase inhibitor. Formestane has poor oral bioavailability and as such is no longer popular as many orally active aromatase inhibitors have been identified. Cells were treated with different aromatase inhibitors anastrozole, formestane, exemestane, and letrozole, or antiestrogens tamoxifen and fulvestrant. UMB-1Ca cells showed significant growth inhibition in response to fulvestrant (100 nM, P < 0.0005) and partial growth inhibition in response to letrozole (100 nM, P < 0.005).

    纯度
    >98%
    储存/保存方法
    -20°C
    基本信息
    别名
    福美司坦
    外观
    白色粉末
    可溶性/溶解性
    DMSO :57 mg/mL (188.5 mM)
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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