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  • FICZ

    • 6-Formylindolo[3,2-b]carbazole
    货号: abs819673
    CAS号: 172922-91-7
    分子式: C19H12N2O
    分子量: 284.31
    产品说明书
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    货号-规格 货期 价格 数量
    abs819673-1mg 1-2周 ¥1706.00
    - +
    abs819673-5mg 1-2周 ¥6484.00
    - +
    大包装询价
    产品描述
    描述
    FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a Kd of 70 pM.
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    6-Formylindolo[3,2-b]carbazole
    外观
    yellow to orange powder
    可溶性/溶解性
    DMSO : 10 mg/mL (35.17 mM; Need ultrasonic and warming)
    生物活性
    In vitro(体外研究)
    FICZ (0.01 nM-1 µM) alone or in combination with 50 nM MNF induces sustained CYP1A1 activity and leads to oxidative stress and activation of apoptosis via a mitochondrial-dependent pathway. In HepG2 cells, FICZ stimulates cell growth at low concentrations but inhibits cell growth at high concentrations. FICZ (10,000-30,000 nM) significantly decreases CEH viability with an estimated LC50 (95% confidence intervals) of 14,000 nM. FICZ shows concentration-dependent effects on EROD activity in CEH cultures, with the mean EC50 values at 3, 8, and 24 h of 0.016 nM, 0.80 nM, and 11 nM, respectively. FICZ treatment increases transcript expression of CYP1A1 in a dose-dependent manner in both the parental iPSC line and the CYP1A1 targeted clone. CYP1 inhibition in the presence of FICZ results in enhanced AHR activation, suggesting that FICZ accumulates in the cell when its metabolism is blocked. CYP1 enzymes plays a role in regulating biological effects of FICZ.
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    • 实验方法 实验条件
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