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  • FCCP
    • 碳酰氰-4-三氟甲氧基苯腙
    货号: abs816229
    CAS号: 370-86-5
    分子式: C10H5F3N4O
    分子量: 254.17
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    货号-规格 货期 价格 数量
    abs816229-10mg 现货 ¥604.00
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    abs816229-50mg 现货 ¥2547.00
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    abs816229-100mg 现货 ¥3645.00
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    大包装询价
    产品描述
    描述

    FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.

    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    中文别名
    碳酰氰-4-三氟甲氧基苯腙
    外观
    yellow owder
    可溶性/溶解性
    DMSO : 25.4 mg/mL (100 mM)
    生物活性
    靶点
    ATPase
    In vitro(体外研究)
    FCCP treatment induces a very rapid 2-fold increase in intracellular Ca2+ concentration that is accompanied by a strong protein synthesis rate inhibition. The translation inhibition correlates with an increased phosphorylation of the α subunit of eIF2 (eIF2α) and a 1.7-fold increase in the double-stranded RNA-dependent protein kinase activity. FCCP treatment also mildly decreases ATP and reactive oxygen species levels. It increases the expression of mitochondrial genes such as Tfam and COXIV while inducing morphological features of quiescent mouse HSCs and abrogating TGF-β signal transduction.
    In vivo(体内研究)
    FCCP significantly reduces mitochondrial membrane potential and ATP production in 8-cell mouse embryos and the number of inner cell mass cells within blastocysts with unchanged blastocyst development. This perturbed embryonic mitochondrial function is concomitant with reduced birth weight in female offspring following embryo transfer, which persists until weaning. Although FCCP-treated males also exhibits reduced glucose tolerance as female, but their insulin sensitivity and adiposity gain between 4 and 14 weeks is unchanged. Reducing mitochondrial function and, thus, decreasing ATP output in the precompacting embryo can influence offspring phenotype.
    参考文献
    参考文献
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