Ethosuximide
- 乙琥胺
货号： abs819383
| 货号-规格 | 货期 | 价格 | 数量 |
| abs819383-500mg | 1-2周 | ￥551.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | Ethosuximide is an anticonvulsant, blocks the low voltage-activated T-type calcium channel used in the treatment of absence seizures unaccompanied by other types of seizures. | |
| 纯度 | 98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 形态 | Solid | |
| 基本信息 | ||
| 别名 | 乙琥胺 | |
| 外观 | white solid | |
| 可溶性/溶解性 | DMSO ：28 mg/mL (198.34 mM) Water ：28 mg/mL (198.34 mM) | |
| 生物活性 | ||
| 靶点 | Calcium Channel | |
| In vitro(体外研究) | Ethosuximide(ETH) enhances hippocampal derived NSC proliferation and neurospheres formation in vitro. Low concentration of ETH induces proliferation of NSC, while higher concentrations of ETH are cytotoxic. Also, ETH activates the PI3K/Akt signal transduction pathway in adult hippocampal NSC in vitro. Blockade of the PI3K/Akt pathway inhibits ETH induced hippocampal NSC neuronal differentiation. | |
| In vivo(体内研究) | Anti-epileptic drug ethosuximide rescues the short lifespan and chemosensory defects exhibited by C. elegans null mutants of dnj-14, the worm orthologue of the DNAJC5 gene mutated in autosomal-dominant adult-onset neuronal ceroid lipofuscinosis. It also ameliorates the locomotion impairment and short lifespan of worms expressing a human Tau mutant that causes frontotemporal dementia. Ethosuximide extends lifespan by inhibiting the function of specific chemosensory neurons. It increases neurogenesis, reduces neurodegeneration, and reverses cognitive impairments in rat model of AD like phenotypes. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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危险品化学品经营许可证(不带存储) 许可证编号：沪(浦)应急管危经许[2022]202585(YS)
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