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  • Ethosuximide
    • 乙琥胺
    货号: abs819383
    CAS号: 77-67-8
    分子式: C7H11NO2
    分子量: 141.17
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    货号-规格 货期 价格 数量
    abs819383-500mg 1-2周 ¥551.00
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    大包装询价
    产品描述
    描述

    Ethosuximide is an anticonvulsant, blocks the low voltage-activated T-type calcium channel used in the treatment of absence seizures unaccompanied by other types of seizures.

    纯度
    98%
    储存/保存方法
    Store at -20° C
    形态
    Solid
    基本信息
    别名
    乙琥胺
    外观
    white solid
    可溶性/溶解性
    DMSO :28 mg/mL (198.34 mM)

    Water :28 mg/mL (198.34 mM)
    生物活性
    靶点
    Calcium Channel
    In vitro(体外研究)
    Ethosuximide(ETH) enhances hippocampal derived NSC proliferation and neurospheres formation in vitro. Low concentration of ETH induces proliferation of NSC, while higher concentrations of ETH are cytotoxic. Also, ETH activates the PI3K/Akt signal transduction pathway in adult hippocampal NSC in vitro. Blockade of the PI3K/Akt pathway inhibits ETH induced hippocampal NSC neuronal differentiation.
    In vivo(体内研究)
    Anti-epileptic drug ethosuximide rescues the short lifespan and chemosensory defects exhibited by C. elegans null mutants of dnj-14, the worm orthologue of the DNAJC5 gene mutated in autosomal-dominant adult-onset neuronal ceroid lipofuscinosis. It also ameliorates the locomotion impairment and short lifespan of worms expressing a human Tau mutant that causes frontotemporal dementia. Ethosuximide extends lifespan by inhibiting the function of specific chemosensory neurons. It increases neurogenesis, reduces neurodegeneration, and reverses cognitive impairments in rat model of AD like phenotypes.
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