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  • Ethinyl Estradiol
    • 炔雌醇
    货号: abs815914
    CAS号: 57-63-6
    分子式: C20H24O2
    分子量: 296.4
    产品说明书
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    货号-规格 货期 价格 数量
    abs815914-100mg 1-2周 ¥509.00
    - +
    abs815914-500mg 1-2周 ¥970.00
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    大包装询价
    产品描述
    描述

    Ethinyl Estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    中文别名
    炔雌醇
    外观
    白色或微黄白色结晶性粉末
    可溶性/溶解性
    DMSO : 55 mg/mL (185.6 mM)

    Ethanol : 55 mg/mL (185.6 mM)
    生物活性
    靶点
    Estrogen receptor
    In vitro(体外研究)
    Ethinyl Estradiol increases respiratory chain activity in both cultured rat hepatocytesand HepG2 cells. Ethinyl estradiol is a strong promoter of hepatocarcinogenesis. Ethinyl Estradiol enhances the transcript levels of nuclear genome- and mitochondrial genome-encoded genes and respiratory chain activity in female rat liver, and also inhibits transforming growth factor beta (TGFbeta)-induced apoptosis in cultured liver slices and hepatocytes from female rats. Ethinyl Estradiol increases the transcript levels of the mitochondrial genome-encoded genes cytochrome oxidase subunits I, II, and III in cultured female rathepatocytes. Ethinyl Estradiol significantly increases both the levels of glutathione (reduced and oxidized forms) per mg protein in mitochondria and nuclei, while the percentage of total glutathione in the oxidized form is not affected.
    In vivo(体内研究)
    Ethinyl Estradiol (50 mg/kg/day) increases anogenital distance and reduces pup body weight at postnatal day 2, accelerates the age at vaginal opening, reduces F1 fertility and F2 litter sizes, and induces malformations of the external genitalia (5 mg/kg) in the female Long-Evans rat. Ethinyl Estradiol increases the number of low density lipoprotein (LDL) receptors in livers of rats, thereby producing a profound fall in plasma cholesterol levels. Ethinyl Estradiol exerts the same effect in livers of male and female rabbits and that the increase in receptor number is correlated with a 6- to 8-fold increase in the levels of receptor mRNA.
    参考文献
    参考文献
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