Ethacrynic acid

Ethacrynic acid is a compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic

A compound classified as a high ceiling diuretic

≥98%

Store at room temperature

Solid

[2,3-Dichloro-4-(2-methylenebutanoyl)phenoxy]acetic acid

Crystalline powder

~1.4 g/cm³ (Predicted)

124-126° C

~480.0° C at 760 mmHg (Predicted)

n²⁰_D 1.56 (Predicted)

Felis catus: IC₅₀ = 1 µM; Aldose reductase: IC₅₀ = 1.15 µM (rat); Trypanosoma brucei: EC₅₀50 = 3.3 µM

pK_a: 3.5

Soluble in ethanol, chloroform, ether, ammonia, carbonates, and methanol. Insoluble in water.

MFCD00056693

3278

200-384-1