ETC-159
- ETC 159，ETC159，ETC 1922159，ETC-1922159，ETC1922159
货号： abs810177
| 货号-规格 | 货期 | 价格 | 数量 |
| abs810177-5mg | 1-2周 | ￥1895.00 | - + |
| abs810177-10mg | 1-2周 | ￥2709.00 | - + |
| abs810177-50mg | 1-2周 | ￥5418.00 | - + |
| abs810177-100mg | 1-2周 | ￥7740.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | ETC-159 is a potent and specific inhibitor of Wnt secretion. ETC-159 inhibits _beta_-catenin reporter activity in a dose-dependent manner with an IC50 of 2.9 nM. | |
| 纯度 | >98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | ETC 159，ETC159，ETC 1922159，ETC-1922159，ETC1922159 | |
| 外观 | Powder | |
| 可溶性/溶解性 | DMSO: ≥ 34 mg/mL | |
| 生物活性 | ||
| 靶点 | Wnt | |
| In vitro(体外研究) | ETC-159 blocks the secretion and activity of all Wnts. ETC-159 has robust activity in multiple cancer models driven by high Wnt signaling. ETC-159 is highly efficacious in molecularly defined colorectal cancers (CRCs) with R-spondin translocations | |
| In vivo(体内研究) | ETC-159 inhibits mouse PORCN with an IC50 of 18.1 nM, whereas the IC50 for Xenopus Porcn is approximately four fold higher (70 nM). ETC-159 is remarkably effective in treating RSPO-translocation bearing colorectal cancer (CRC) patient-derived xenografts. ETC-159 exhibits good oral pharmacokinetics in mice allowing preclinical evaluation via oral administration. After a single oral dose of 5 mg/kg, ETC-159 is rapidly absorbed into the blood with a Tmax of ~0.5 h and oral bioavailability of 100%. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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