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  • ETC-159
    • ETC 159,ETC159,ETC 1922159,ETC-1922159,ETC1922159
    货号: abs810177
    CAS号: 1638250-96-0
    分子式: C19H17N7O3
    分子量: 391.38
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810177-5mg 1-2周 ¥1895.00
    - +
    abs810177-10mg 1-2周 ¥2709.00
    - +
    abs810177-50mg 1-2周 ¥5418.00
    - +
    abs810177-100mg 1-2周 ¥7740.00
    - +
    大包装询价
    产品描述
    描述
    ETC-159 is a potent and specific inhibitor of Wnt secretion. ETC-159 inhibits _beta_-catenin reporter activity in a dose-dependent manner with an IC50 of 2.9 nM.
    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    中文别名
    ETC 159,ETC159,ETC 1922159,ETC-1922159,ETC1922159
    外观
    Powder
    可溶性/溶解性
    DMSO: ≥ 34 mg/mL
    生物活性
    靶点
    Wnt
    In vitro(体外研究)
    ETC-159 blocks the secretion and activity of all Wnts. ETC-159 has robust activity in multiple cancer models driven by high Wnt signaling. ETC-159 is highly efficacious in molecularly defined colorectal cancers (CRCs) with R-spondin translocations
    In vivo(体内研究)
    ETC-159 inhibits mouse PORCN with an IC50 of 18.1 nM, whereas the IC50 for Xenopus Porcn is approximately four fold higher (70 nM). ETC-159 is remarkably effective in treating RSPO-translocation bearing colorectal cancer (CRC) patient-derived xenografts. ETC-159 exhibits good oral pharmacokinetics in mice allowing preclinical evaluation via oral administration. After a single oral dose of 5 mg/kg, ETC-159 is rapidly absorbed into the blood with a Tmax of ~0.5 h and oral bioavailability of 100%.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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