ETC-159
- ETC 159,ETC159,ETC 1922159,ETC-1922159,ETC1922159
货号: abs810177
货号-规格 | 货期 | 价格 | 数量 |
abs810177-5mg | 1-2周 | ¥1895.00 | - + |
abs810177-10mg | 1-2周 | ¥2709.00 | - + |
abs810177-50mg | 1-2周 | ¥5418.00 | - + |
abs810177-100mg | 1-2周 | ¥7740.00 | - + |

产品描述 | ||
描述 | ETC-159 is a potent and specific inhibitor of Wnt secretion. ETC-159 inhibits _beta_-catenin reporter activity in a dose-dependent manner with an IC50 of 2.9 nM. | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | ETC 159,ETC159,ETC 1922159,ETC-1922159,ETC1922159 | |
外观 | Powder | |
可溶性/溶解性 | DMSO: ≥ 34 mg/mL | |
生物活性 | ||
靶点 | Wnt | |
In vitro(体外研究) | ETC-159 blocks the secretion and activity of all Wnts. ETC-159 has robust activity in multiple cancer models driven by high Wnt signaling. ETC-159 is highly efficacious in molecularly defined colorectal cancers (CRCs) with R-spondin translocations | |
In vivo(体内研究) | ETC-159 inhibits mouse PORCN with an IC50 of 18.1 nM, whereas the IC50 for Xenopus Porcn is approximately four fold higher (70 nM). ETC-159 is remarkably effective in treating RSPO-translocation bearing colorectal cancer (CRC) patient-derived xenografts. ETC-159 exhibits good oral pharmacokinetics in mice allowing preclinical evaluation via oral administration. After a single oral dose of 5 mg/kg, ETC-159 is rapidly absorbed into the blood with a Tmax of ~0.5 h and oral bioavailability of 100%. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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