Estrone-2,4-D2

Estrone-d₂ is intended for use as an internal standard for the quantification of estrone (Item Nos. ISO60165 | 10006485) by GC- or LC-MS. Estrone is one of the three naturally occurring estrogens, the others being estradiol (Item Nos. ISO60155 | 10006315) and estriol (Item Nos. ISO60164 | 10006484).¹ Estrone is synthesized from androstenedione (Item No. ISO60161) by the aromatase enzyme system in the ovaries and placenta, and is also synthesized from estradiol by 17-hydroxy steroid dehydrogenase in the liver.^1,2 Serum concentrations of estrone in premenopausal women fluctuate according to the menstrual cycle and becomes the most predominant estrogen in postmenopausal women.¹ The binding affinities of estrone to the estrogen receptors α and β are approximately 60% and 37% relative to estradiol.¹

≥98%

Store at -20℃

E₁-d₂;

1.Gruber, C.J.,Tschugguel, W.,Schneeberger, C., et al. Production and actions of estrogens. New England Journal of Medicine 346(5), 340-352 (2002).

2.Vance, D.E. Cholesterol and related derivatives. Biochemistry 2nd ed., 725-748 (1988).