Estriol-d2

Estriol-d₂ is intended for use as an internal standard for the quantification of estriol (Item Nos. ISO60164 | 10006484) by GC- or LC-MS. Estriol is a metabolite of estradiol (Item Nos. ISO60155 | 10006315) and a major estrogen produced in the later stages of pregnancy. In a longitudinal study in healthy pregnant women, total plasma estriol levels increased from <10 ng/ml at 8-10 weeks gestation to approximately 150 ng/ml at week 38.¹ The majority of the estriol synthesized in the later stages of pregnancy originates from fetal dehydroepiandrosterone sulfate (DHEAS; Item No. 15873) and serves as a direct marker of fetal adrenal gland activity.² Saliva contains primarily unbound and unconjugated estriol and is commonly used for monitoring estriol levels.^2,3 Plasma levels of estriol in males and non-pregnant females is less than 2 ng/ml.⁴

≥98%

Store at -20℃

E₃-d₂;16α-hydroxy-17β-Estradiol-d₂;1,3,5(10)-Estratriene-3,16α,17β-triol-d₂;

1.Peter, M.,Dörr, H.G. and Sippell, W.G. Changes in the concentrations of dehydroepiandrosterone sulfate and estriol in maternal plasma during pregnancy: A longitudinal study in healthy women throughout gestation and at term. Hormone Research 42, 278-281 (1994).

2.Goodwin, T.M. A role for estriol in human labor, term and preterm. American Journal of Obstetics and Gynecology 180, S208-S213 (1999).

3.Voss, H.F. Hormonal pathways of preterm birth. American Journal of Obstetics and Gynecology 180, S226-S231 (1999).

4.. Steroid levels in humans. (1999).