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  • Estradiol
    • 雌二醇; β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol
    货号: abs812844
    CAS号: 50-28-2
    分子式: C18H24O2
    分子量: 272.38
    产品说明书
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    货号-规格 货期 价格 数量
    abs812844-50mg 1-2周 ¥639.00
    - +
    abs812844-200mg 1-2周 ¥992.00
    - +
    大包装询价
    产品描述
    描述
    Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    中文别名
    雌二醇; β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol
    外观
    White to off-white powder
    可溶性/溶解性
    DMSO : ≥ 50 mg/mL (183.57 mM)
    Ethanol : 20 mg/mL (73.43 mM; Need ultrasonic)
    生物活性
    靶点
    Estrogen receptor
    In vitro(体外研究)
    Estradiol induces new dendritic spines and synapses on hippocampal CA1 pyramidal cells. Estradiol treatment resulted in a 46% increase in NMDA receptor binding. Estradiol treatment increases NMDA receptor binding in parallel with dendritic spine and synapse density. Estradiol treatment results in increased sensitivity of CA1 pyramidal cells to NMDA receptor-mediated synaptic input and that this increase is well correlated with the estradiol-induced increase in dendritic spine density in the apical dendritic tree of these cells. 17 beta-estradiol is found to reduce Ba2+ entry reversibly via Ca2+ channels in acutely dissociated and cultured neostriatal neurons. 17 alpha-Estradiol also reduces Ba2+ currents but is significantly less effective than 17 beta-estradiol in rat neostriatal neurons. 17 beta-estradiol exerts a dose-dependent inhibition of IL-1-, TNF-, and IL-1 and TNF-induced production of bioassayable IL-6. Estradiol inhibits both TNF-induced IL-6 production and osteoclast development in primary bone cell cultures derived from neonatal murine calvaria.
    In vivo(体内研究)
    Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. Estradiol alone can reverse the ovariectomy-induced decrease in spine density. Estradiol combined with Progesterone initially increases spine density for a period of 2 to 6 hours but then results in a much sharper decrease than is observed following estradiol alone.
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    • 实验方法 实验条件
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