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  • Estradiol
    • β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol
    货号: abs812844
    CAS号: 50-28-2
    分子式: C18H24O2
    分子量: 272.38
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    货号-规格 货期 价格 数量
    abs812844-50mg 现货 ¥639.00
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    abs812844-200mg 1-2周 ¥992.00
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    大包装询价
    产品描述
    描述

    Estradiol (E2) is a potent mammalian?estrogenic?hormone that is produced in the ovaries (by the granulosa cells), placenta, testis and possibly the adrenal cortex.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol
    外观
    Powder
    可溶性/溶解性
    Ethanol:5mg/mL(18.35mM)

    DMSO:54mg/ml(198.25 mM)
    生物活性
    靶点
    Estrogen receptor
    In vitro(体外研究)
    Estradiol induces new dendritic spines and synapses on hippocampal CA1 pyramidal cells. Estradiol treatment resulted in a 46% increase in NMDA receptor binding. Estradiol treatment increases NMDA receptor binding in parallel with dendritic spine and synapse density. Estradiol treatment results in increased sensitivity of CA1 pyramidal cells to NMDA receptor-mediated synaptic input and that this increase is well correlated with the estradiol-induced increase in dendritic spine density in the apical dendritic tree of these cells. 17 beta-estradiol is found to reduce Ba2+ entry reversibly via Ca2+ channels in acutely dissociated and cultured neostriatal neurons. 17 alpha-Estradiol also reduces Ba2+ currents but is significantly less effective than 17 beta-estradiol in rat neostriatal neurons. 17 beta-estradiol exerts a dose-dependent inhibition of IL-1-, TNF-, and IL-1 and TNF-induced production of bioassayable IL-6. Estradiol inhibits both TNF-induced IL-6 production and osteoclast development in primary bone cell cultures derived from neonatal murine calvaria.
    In vivo(体内研究)
    Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. Estradiol alone can reverse the ovariectomy-induced decrease in spine density. Estradiol combined with Progesterone initially increases spine density for a period of 2 to 6 hours but then results in a much sharper decrease than is observed following estradiol alone.
    参考文献
    参考文献
    [1] Woolley CS, et al. J Neurosci, 1997, 17(5), 1848-1859.
    [2] Mermelstein PG, et al. J Neurosci, 1996, 16(2), 595-604.
    [3] Girasole G, et al. J Clin Invest, 1992, 89(3), 883-891.
    [4] Woolley CS, et al. J Neurosci, 1992, 12(7), 2549-2554.
    [5] Woolley CS, et al. J Comp Neurol, 1993, 336(2), 293-306.
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