α-雌二醇

α-Estradiol is an endogenous ligand for estrogen receptors ERα (K_i = 0.2 nM) and ERβ (K_i = 1.2 nM). Studies indicate that α-Estradiol is a short acting estrogen which only forms complexes with estrogen ligand receptors for a short period of time. These studies suggest that α-estradiol is beneficial in studying the affects caused by the MAPK signaling cascade such as cell division, neuronal differentiation, and neuronal survival in the developing brain. Furthermore, α-estradiol inhibits the influx of calcium in human aortic smooth muscle cells.

A ligand for ERα and ERβ

98%

Store at room temperature

Solid

17a-雌二醇；雌二醇;17a-Estradiol；Epiestradiol

白色至淡黄色粉末

~1.2 g/cm³ (Predicted)

216-219° C

~445.9° C at 760 mmHg (Predicted)

n²⁰_D 1.60 (Predicted)

α20/D +48°, c = 0.9 in Dioxane; α20/D +55.1°, c = 0.4 in Dioxane

MCF7: EC₅₀50 = 0.38 nM (human); ERα : EC₅₀50 = 1.5 nM (human); ERβ: EC₅₀50 = 4.5 nM (human); Androgen Receptor: IC₅₀ = 75.86 µM (rat)

pK_a: 10.27 (Predicted)

ERα receptors: K_i= 0.2 nM; ERβ receptors: K_i= 1.2 nM

Soluble in DMSO (100 mM), ethanol (50 mg/ml), methanol, and chloroform (1:435). Insoluble in water.

MFCD00064144

68570

2698044

200-354-8