Esmolol hydrochloride

>98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

盐酸艾司洛尔

白色或类白色结晶性粉末

Ethanol ：61 mg/mL (184.2 mM)

DMSO ：61 mg/mL (184.2 mM)

Water ：61 mg/mL (184.2 mM)

beta-adrenergic receptor

Esmolol contains one asymmetric centre and exists as an enantiomeric pair, the (-)-enantiomer is active and the (+)-enantiomer is inactive, which is analogous to other P-blockers that have an oxypropranolamine nucleus. Esmolol has a rapid onset and offset of activity, the primary site of activity of Esmolol is on sinus node and atrioventricular (AV) nodal conduction systems.

Esmolol (20 mg/kg) infusion in sepsis improves oxygen utilization of myocardium and preserves myocardial function in septic rats. Esmolol (5 mg/kg, i.v.) produces a dose-dependent decrease in heart rate (HR) in rabbits, with the maximum percent reductions of 13%. Esmolol (5 mg/kg, i.v.) produces a dose-dependent decrease in mean arterial pressure (MAP) in rabbits, with the maximum percent reductions of 38.2%. Esmolol (300 mg/kg) significantly decreases the heart rate, rate-pressure product, left ventricular contraction, cardiac output, and relative refractory period of the right ventricle, suppresses the AV nodal conduction, and increases the effective refractory period of the right ventricle and the preload of the left ventricle in canine. Esmolol (300 mg/kg) significantly reduces the isoproterenol-induced increase in heart rate and ventricular contraction in canine.