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  • Escitalopram Oxalate
    • 依他普仑草酸盐;(S)-(+)Citalopram oxalate
    货号: abs813629
    CAS号: 219861-08-2
    分子式: C20H21FN2O.C2H2O4
    分子量: 414.43
    产品说明书
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    货号-规格 货期 价格 数量
    abs813629-10mg 1-2周 ¥607.00
    - +
    abs813629-50mg 1-2周 ¥725.00
    - +
    abs813629-100mg 1-2周 ¥983.00
    - +
    大包装询价
    产品描述
    描述

    Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.

    纯度
    >98%
    储存/保存方法
    -20°C 冷藏长期储存,常温运输及临时存放
    基本信息
    别名
    依他普仑草酸盐;(S)-(+)Citalopram oxalate
    外观
    白色或类白色结晶性粉末
    可溶性/溶解性
    DMSO :41.4 mg/mL (100 mM)

    Water :20.7 mg/mL (50 mM)
    生物活性
    靶点
    5-HT
    In vitro(体外研究)
    Escitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of escitalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. In vitro studies show that escitalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram is found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase.
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