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  • Entecavir Monohydrate

    • ETV; Baraclude; SQ 34676; BMS 200475; SQ34676; BMS200475; SQ-34676; BMS-200475
    货号: abs811046
    CAS号: 209216-23-9
    分子式: C12H15N5O3·H2O
    分子量: 295.3
    产品说明书
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    货号-规格 货期 价格 数量
    abs811046-5mg 现货 ¥789.00
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    abs811046-10mg 现货 ¥1323.00
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    abs811046-50mg 现货 ¥2668.00
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    abs811046-100mg 现货 ¥3628.00
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    大包装询价
    产品描述
    描述

    Entecavir is a nucleoside analog (more specifically, a guanosine analogue) that inhibits reverse transcription, DNA replication and transcription in the viral replication process. Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    ETV; Baraclude; SQ 34676; BMS 200475; SQ34676; BMS200475; SQ-34676; BMS-200475
    可溶性/溶解性
    DMSO Solubility: 59 mg/mL (199.8 mM)
    生物活性
    靶点
    Reverse Transcriptase
    In vitro(体外研究)
    Entecavir-triphosphate is a highly potent inhibitor of wild-type HBV Pol and is 100- to 300-fold more potent than lamivudine-triphosphate against 3TC-resistant HBV Pol. Entecavir inhibits the replication of 3TC-resistant HBV, but 20- to 30-fold higher concentrations are required. Entecavir results in an impressive reduction of serum viral DNA with covalently closed circular DNA and hepatitis B viral core antigen negativity in liver biopsy specimens. Entecavir has potent activity (EC50, 0.1 nM) against HIV in a unique single-cycle, single-cell-based pseudovirus assay (24) with CD4+ lymphocytes using a green fluorescent protein reporter fluorescence-activated cell sorter assay as the endpoint.
    In vivo(体内研究)
    Entecavir causes a 4-log drop in serum DHBV DNA levels within 80 days and a slower 2- to 3-log drop in serum DHBV surface antigen (DHBsAg) levels within 120 days in ducks. Entecavir treatment reduces DHBV DNA replicative intermediates 70-fold in the liver, while the level of the stable, template form, covalently closed circular DNA decreases only 4-fold in ducks. Entecavir treatment reduces both the intensity of antigen staining and the percentage of antigen-positive hepatocytes in the liver, but the intensity of antigen staining in bile duct cells appeares not to be effected in ducks.
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