货号: abs821096
货号-规格 | 货期 | 价格 | 数量 |
abs821096-5mg | 4周 | ¥1045.00 | - + |
abs821096-50mg | 4周 | ¥6483.00 | - + |

产品描述 | |
描述 | Enasidenib mesylate is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes. |
纯度 | 98% |
储存/保存方法 | store at -20℃ for one year(Powder) |
生物活性 | |
In vitro(体外研究) | Enasidenib (AG-221) reverses the effects of mutant IDH2 on DNA methylation in mutant stem/progenitor cells. Enasidenib induces differentiation and impairs self-renewal of IDH2-mutant leukemia cells, effects that are further enhanced by simultaneous inhibition of Flt3ITD. Enasidenib (AG-221) therapy induces differentiation of leukemic cells, with an increase in the CD11b+ population and a decrease in the c-Kit+ population in the peripheral blood at 2 wks. |
In vivo(体内研究) | Enasidenib (AG-221) reverses the effects of mutant IDH2 on DNA methylation in mutant stem/progenitor cells. Enasidenib induces differentiation and impairs self-renewal of IDH2-mutant leukemia cells, effects that are further enhanced by simultaneous inhibition of Flt3ITD. Enasidenib (AG-221) therapy induces differentiation of leukemic cells, with an increase in the CD11b+ population and a decrease in the c-Kit+ population in the peripheral blood at 2 wks. |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
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