货号： abs821096
| 货号-规格 | 货期 | 价格 | 数量 |
| abs821096-5mg | 4周 | ￥1045.00 | - + |
| abs821096-50mg | 4周 | ￥6483.00 | - + |
大包装询价| 产品描述 | |
| 描述 | Enasidenib mesylate is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes. |
| 纯度 | 98% |
| 储存/保存方法 | store at -20℃ for one year（Powder） |
| 生物活性 | |
| In vitro(体外研究) | Enasidenib (AG-221) reverses the effects of mutant IDH2 on DNA methylation in mutant stem/progenitor cells. Enasidenib induces differentiation and impairs self-renewal of IDH2-mutant leukemia cells, effects that are further enhanced by simultaneous inhibition of Flt3ITD. Enasidenib (AG-221) therapy induces differentiation of leukemic cells, with an increase in the CD11b+ population and a decrease in the c-Kit+ population in the peripheral blood at 2 wks. |
| In vivo(体内研究) | Enasidenib (AG-221) reverses the effects of mutant IDH2 on DNA methylation in mutant stem/progenitor cells. Enasidenib induces differentiation and impairs self-renewal of IDH2-mutant leukemia cells, effects that are further enhanced by simultaneous inhibition of Flt3ITD. Enasidenib (AG-221) therapy induces differentiation of leukemic cells, with an increase in the CD11b+ population and a decrease in the c-Kit+ population in the peripheral blood at 2 wks. |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
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Certificate of Analysis(COA)
