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  • Enasidenib mesylate
    货号: abs821096
    CAS号: 1650550-25-6
    分子式: C20H21F6N7O4S
    分子量: 569.48
    产品说明书
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    货号-规格 货期 价格 数量
    abs821096-5mg 4周 ¥1045.00
    - +
    abs821096-50mg 4周 ¥6483.00
    - +
    大包装询价
    产品描述
    描述
    Enasidenib mesylate is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes.
    纯度
    98%
    储存/保存方法
    store at -20℃ for one year(Powder)
    生物活性
    In vitro(体外研究)
    Enasidenib (AG-221) reverses the effects of mutant IDH2 on DNA methylation in mutant stem/progenitor cells. Enasidenib induces differentiation and impairs self-renewal of IDH2-mutant leukemia cells, effects that are further enhanced by simultaneous inhibition of Flt3ITD. Enasidenib (AG-221) therapy induces differentiation of leukemic cells, with an increase in the CD11b+ population and a decrease in the c-Kit+ population in the peripheral blood at 2 wks.
    In vivo(体内研究)
    Enasidenib (AG-221) reverses the effects of mutant IDH2 on DNA methylation in mutant stem/progenitor cells. Enasidenib induces differentiation and impairs self-renewal of IDH2-mutant leukemia cells, effects that are further enhanced by simultaneous inhibition of Flt3ITD. Enasidenib (AG-221) therapy induces differentiation of leukemic cells, with an increase in the CD11b+ population and a decrease in the c-Kit+ population in the peripheral blood at 2 wks.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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