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  • Ellagic acid

    • 鞣花酸;Elagostasine;Gallogen
    货号: abs814696
    CAS号: 476-66-4
    分子式: C14H6O8
    产品说明书
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    货号-规格 货期 价格 数量
    abs814696-50mg 1-2周 ¥670.00
    - +
    abs814696-500mg 1-2周 ¥2817.00
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    大包装询价
    产品描述
    描述

    Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC50 of 40 nM and a Ki of 20 nM.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    鞣花酸;Elagostasine;Gallogen
    外观
    powder
    可溶性/溶解性
    DMSO : 0.75 mg/mL (2.48 mM; Need ultrasonic)

    Ethanol : 0.2 mg/mL (0.65 mM)
    生物活性
    靶点
    CK2
    In vitro(体外研究)
    Ellagic acid is a potent CK2 inhibitor, with an IC50 of 40 nM and a Ki of 20 nM. Ellagic acid also blocks other kinases such as LYN, PKA, SYK, GSK3, FGR and CK1, with IC50s of 2.9, 3.5, 4.3, 7.5, 9.4 and 13.0 μM, respectively, and shows no obvious effects on DYRK1a, CSK, NPM-ALK, RET and FLT3 (IC50s > 40 μM). Ellagic acid (5-100 μM) shows inhibitory activities against Karpas299, SUDHL1, SR786, and FE-PD cell lines. Ellagic acid (10 μM) exhibits cytotoxic effects on MCF-7 cells after treatment of radiation. Ellagic acid (10 μM) in combination with Irradiation (IR) significantly abridges the capacity of MCF-7 cells to form colonies equated with individual treatments. Ellagic acid with IR also induces cell apoptosis, and facilitates the upregulation of pro-apopttotic Bax and downregulation of Bcl-2 in MCF-7 cells.
    In vivo(体内研究)
    Ellagic acid (EA; 10 mg/kg/day; p.o., 14 days) strongly decreases MDA brain content by 17%, and reduces the levels of brain TNF-α by 42% in rats. Ellagic acid markedly increases the reduced brain contents of 5-HT (39%), dopamine (DA, 71%), and norepinephrine (NE, 77%). Ellagic acid (10 mg/kg, p.o., 14 days) causes decreased histopathological changes induced by Doxorubicin in rats.
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    • 实验方法 实验条件
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