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  • Ellagic Acid, Dihydrate

    • 鞣花酸水合物
    货号: abs814697
    CAS号: 314041-08-2
    分子式: C14H6O8•H2O
    分子量: 320.21
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    货号-规格 货期 价格 数量
    abs814697-50mg 1-2周 ¥497.00
    - +
    abs814697-500mg 1-2周 ¥2084.00
    - +
    大包装询价
    产品描述
    描述

    Ellagic acid is a potent inhibitor of protein kinase CK2 with IC50s of 0.04, 2.9 and 3.5 μM for CK2, Lyn and PKA respectively. It shows potent antioxidant, anti-mutagenic and antidepressant properties.

    纯度
    ≥96%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    鞣花酸水合物
    外观
    Slightly Beige Powder
    可溶性/溶解性
    DMSO :2 mg/mL (6.24 mM)
    生物活性
    靶点
    CK2,Lyn,PKA
    In vitro(体外研究)
    Ellagic acid (EA) is able to inhibit the growth of several cancer cells. EA inhibited cell proliferation in a dose- and time-dependent manner by arresting both cell lines at the G1 phase of the cell cycle, which were from elevating p53 and Cip1/p21 and decreasing cyclin D1 and E levels. EA also induced caspase-3-mediated apoptosis by increasing the Bax : Bcl-2 ratio and restored anoikis in ES-2 and PA-1 cells. It is well known to have a free radical scavenging activity. EA reversed epithelial to mesenchymal transition by up-regulating E-cadherin and down-regulating Vimentin.
    In vivo(体内研究)
    A 90-day subchronic toxicity study further demonstrated that orally feeding EA (9.4, 19.1, 39.1 g/kg b.w., resp.) could not induce mortality or treatment-related clinical signs throughout the experimental period on F344 rats, indicating the low toxicity of EA to mammalians. Furthermore, EA exhibits potent anticancer and anticarcinogenesis activities towards breast, colorectal, oral, prostate, pancreatic, bladder, neuroblastoma, melanoma, and lymphoma cells. Treatment of PANC-1 xenografted mice with EA resulted in significant inhibition in tumor growth and prolong mice survival rate.
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