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  • Droperidol
    • 氟哌利多;Dehydrobenzperidol
    货号: abs813614
    CAS号: 548-73-2
    分子式: C22H22FN3O2
    分子量: 379.43
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs813614-25mg 1-2周 ¥424.00
    - +
    abs813614-50mg 1-2周 ¥434.00
    - +
    abs813614-100mg 1-2周 ¥846.00
    - +
    abs813614-200mg 1-2周 ¥1524.00
    - +
    大包装询价
    产品描述
    描述

    Droperidol is a potent antagonist of dopamine subtype 2 receptors in the limbic system.

    纯度
    >98%
    储存/保存方法
    -20°C
    基本信息
    别名
    氟哌利多;Dehydrobenzperidol
    外观
    类白色至浅黄色结晶性粉末
    可溶性/溶解性
    DMSO :37.9 mg/mL (100 mM)
    生物活性
    In vitro(体外研究)
    Droperidol produces mild α-adrenergic blockade and peripheral vascular dilation. Droperidol has been shown to block potassium efflux in the myocardium in isolated animal ventricular myocytes, resulting in a dose-dependent delay in repolarization. Droperidol has also been shown to induce early depolarizations in isolated animal Purkinje fibers.
    In vivo(体内研究)
    Droperidol (0.01 mM-0.3 mM) increases in a dose-dependent fashion action potential duration (APD) without altering the other parameters in rabbit Purkinje fibers stimulated at 60 pulses/min. Droperidol (1 mM-3 mM) leads to the reversal of the prolonging effect in rabbit Purkinje fibers. Droperidol (10 mM-30 mM) produces shortening in APD at 50% repolarization concomitantly with a significant decrease in Vmax, action potential amplitude and resting membrane potential in rabbit Purkinje fibers. Droperidol exerts a dual effect on repolarization, prolongation with low concentrations with development of EADs and subsequent triggered activity in rabbit Purkinje fibers. Droperidol (3 mg/kg, single dose) decreases dose dependently not only locomotion and rearing frequencies in the open-field but also the apomorphine effects of rats. Droperidol (3 mg/kg, long term administration) induces significant tolerance to all parameters of activity recorded in the open-field in rats. Droperidol withdrawn produces an augmented responsiveness to apomorphine-induced stereotyped behavior.
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