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  • Dp44mT
    • Iron Chelator, Dp44mT
    货号: abs810146
    CAS号: 152095-12-0
    分子式: C14H15N5S
    分子量: 285.37
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810146-5mg 1-2周 ¥947.00
    - +
    abs810146-10mg 1-2周 ¥1353.00
    - +
    abs810146-50mg 1-2周 ¥2709.00
    - +
    abs810146-100mg 1-2周 ¥3870.00
    - +
    大包装询价
    产品描述
    描述

    Dp44mT is a potent iron chelator, which shows selective antitumor activity.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    Iron Chelator, Dp44mT
    外观
    yellow to orange Powder
    可溶性/溶解性
    DMSO :57 mg/mL warmed (199.74 mM)

    Ethanol :47 mg/mL warmed (164.69 mM)

    Water : Soluble

    生物活性
    靶点
    iron
    In vitro(体外研究)
    Dp44mT shows pronounced antiproliferative effects in SK-N-MC, SK-Mel-28, and MCF-7 cells with IC50 of 30 nM, 60 nM, and 60 nM, respectively, while no effects on normal MRC-5 fibroblasts. Dp44mT inhibits cellular Fe uptake from Fe-Tf in SK-N-MC neuroepithelioma and M109 cells, and induces cell apoptosis. In MDA-MB-231 cells, Dp44mT specifically targets topoisomerase topo2α, and thus causes DNA damage. Dp44mT, as a Pgp substrate, also overcomes multidrug resistance by the hijacking of lysosomal P-glycoprotein (Pgp).
    In vivo(体内研究)
    In CD2F1 mice bearing M109 tumors, Dp44mT (0.4 mg/kg, i.v.) inhibits tumor growth in a dose-dependent manner.
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